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边缘系统与耳鸣

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摘要 耳鸣是在无外界相应声源情况下耳内的一种主观的声音感觉.以往大多数学者认为耳鸣的形成与耳蜗毛细胞和听神经的形态和功能改变相关,随着磁共振成像技术（magnetic resonance imaging,MRI）和正电子发射断层成像技术（positron emission tomography,PET）应用于耳鸣发生机制的研究,学者们发现耳鸣的发生与听觉中枢相关,尤其是边缘系统.
作者 朱小丽 焦甲勋 刘砚星
机构地区 河北医科大学药理学教研室
出处 《国际耳鼻咽喉头颈外科杂志》 2013年第1期54-56,共3页 International Journal of Otolaryngology-Head and Neck Surgery
基金 河北省自然科学基金资助项目（C2011206306）,国家自然科学基金资助项目（30600125）
关键词 耳鸣(Tinnitus) 磁共振成像(Magnetic Resonance Imaging) 正电子层发射断层成像技术(Positron Emission Tomography) 边缘系统(Limbic System)
分类号 R764.45 [医药卫生—耳鼻咽喉科]
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参考文献27

  • 1Melcher JR,Sigalovsky IS,Guinan JJ,et al.Lateralized tinnitus studied with functional magnetic resonance imaging:abnormal inferior colliculus activation.JNeurophysiol,2000,83(2):1058-1072.
  • 2Plewnia C,Reimold M,Najib A,et al.Dose-dependent attenuation of auditory phantom perception (tinnitus) by PETguided repetitive transcranial magnetic stimulation.Hum Brain Mapp,2007,28 (3):238-246.
  • 3Liu Y,Zhang H,Li X,et al.Inhibition of voltage-gated channel currents in rat auditory cortex neurons by salicylate.Neuropharmacology,2007,53 (7):870-880.
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  • 7Weisz N,Moratti S,Meinzer M,et al.Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography.PLoS Med,2005,2(6):e153.
  • 8Dobie RA.Depression and tinnitus.Otolaryngol Clin North Am,2003,36 (2):383-388.
  • 9Mayberg HS,Lozano AM,Voon V,et al.Deep brainstimulation for treatment-resistant depression.Neuron,2005,45(5):651-660.
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二级参考文献7

  • 1张金赫,徐海峰,王锦玲.PET在头颈部肿瘤中的应用进展[J].临床耳鼻咽喉科杂志,2004,18(6):379-381. 被引量：7
  • 2LOCKWOOD A H, SALVI R J, COAD M L, et al. The functional neuroanatomy of tinnitus: evidence for limbic system links and neural plasticity [ J ]. Neurology, 1998, 50 ( I ) : 114 - 120.
  • 3MUHLNICKEL W, ELBERT T, TAUB E, et al. Reorganization of auditory cortex in tinnitus[ J]. Proc Natl Acad Sci USA, 1998, 95 (17) : 10 340 -10 343.
  • 4WANG Hong - tian, TIAN Jia - he, YIN Da - yi, et al. Regional glucose metabolic increases in left auditory cortex in tinnitus patients: a preliminary study with positron emission tomography[ J]. Chin Med J(Engl), 2001, 114(8) : 848 -851.
  • 5GARDNER A, PAGANI M, JACOBSSON H,et al. Differences in resting state regional cerebral blood flow assessed with 99mTc - HMPAO SPECT and brain atlas matching between depressed patients with and without tinnitus [ J ]. Nucl Med Commun, 2002, 23 (5) : 429 - 439.
  • 6EICHHAMMER P, LANGGUTH B, MARIENHAGEN J, et al. Neuronavigated repetitive transcranial magnetic stimulation in patients with tinnitus: a short ease series [ J ]. Biol Psychiatry, 2003, 54(8) : 862 -865.
  • 7CACACE A T. Expanding the biological basis of tinnitus: crossmodal origins and the roleoneuroplasticity [ J]. Hear Res, 2003, 175(1 -2) : 112 -132.

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国际耳鼻咽喉头颈外科杂志
2013年 第1期

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