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甲状腺髓样癌的分子病因学和靶向治疗进展 被引量：2

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摘要 甲状腺髓样癌（medullary thyroid carcinoma,MTC）与转染重排基因突变、哺乳动物雷帕霉素靶蛋白细胞间信号通路活化和ras基因突变等多种基因事件密切相关.以分子病因学研究为基础的靶向治疗在转移性或局部进展、难治性MTC中显示了良好的治疗前景.随着随机临床试验的开展和新型靶向药物的应用,必将为MTC患者提供更加有效的、个体化的治疗选择.
作者 楼建林 郭良 赵坚强
机构地区 浙江省肿瘤医院头颈外科
出处 《国际耳鼻咽喉头颈外科杂志》 2013年第4期230-233,共4页 International Journal of Otolaryngology-Head and Neck Surgery
关键词 甲状腺肿瘤(Thyroid Neoplasms) 癌 髓样(Carcinoma Medullary) 原癌基因(Proto-Oncogenes) 分子生物学(Molecular Biology) 分子靶向治疗(Molecular Targeted Therapy)
分类号 R736.1 [医药卫生—肿瘤]
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参考文献30

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同被引文献28

  • 1柴红,陈泽泉,余永利.甲状腺髓样癌靶向治疗新进展[J].上海交通大学学报（医学版）,2011,31(10):1470-1474. 被引量：3
  • 2张喜卿,张哉根,张同全,孙明祥,孙天玉.甲状腺髓样癌16例临床病理分析[J].诊断病理学杂志,2005,12(2):112-114. 被引量：6
  • 3Kebebew E,Ituarte PH,Siperstein AE,et al. Medullary thyroid car-cinoma: clinical characteristics, treatment, prognostic factors, and acomparison of staging systems [ J ]. Cancer, 2000,88 ( 5 ) : 1139-1148.
  • 4Hofstra RM,Landsvater RM,Ceccherini I,et al. A mutation in theRET proto-oncogene associated with multiple endocrine neoplasiatype 26 and sporadic medullary thyroid carcinoma [ J]. Nature,1994,367(6461) :375 -376.
  • 5Castellone MD, Santoro M. Dysregulated RET signaling in thyroidcancer[ J]. Endocrinol Metab Clin North Am, 2008,37 (2) : 363-374.
  • 6Yang KP,Castillo SG,Nguyen CV,et al. C-myc,N-myc,N-ras,andc-erb-B :lack of amplification or rearrangement in human medullarythyroid carcinoma and a derivative cell line[ J]. Anticancer Res,1990,10(1) :189 -92.
  • 7Yana I,Nakamura T,Shin E,et al. Inactivation of the p53 gene isnot required for tumorigenesis of medullary thyroid carcinoma orpheochromocytoma [ J ]. Jpn J Cancer Res, 1992, 83 ( 11 ):1113-1116.
  • 8Reubi JC,Chayvialle JA,Franc B,et al. Somatostatin receptors andsomatostatin content in medullary thyroid carcinomas[ J]. Lab In-vest, 1991,64(4) :567 -573.
  • 9陆凡倩,陈晓红.甲状腺髓样癌治疗进展.国际耳鼻咽喉头颈外科杂志,2015,39:46-51.
  • 10Samulski TD, Livolsi VA, Montone K, et al. The variable pathologic presentations of medullary and micro-medullary thyroid carcinoma : An institutional experience. Pathol Res Pract, 2014, 210: 182-185.

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国际耳鼻咽喉头颈外科杂志
2013年 第4期

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