摘要
目的:研究预知子Akebia trifoliata的化学成分。方法:利用各种色谱技术进行分离,根据所得单体化学成分的理化性质与光谱数据鉴定其结构。结果:从预知子中分离得到10个已知成分,分别鉴定为3-O-β-D-吡喃葡萄糖(1→3)-α-L-吡喃鼠李糖-(1→2)-α-L-吡喃阿拉伯糖-常春藤皂苷(1),3-O-β-D-吡喃阿拉伯糖-(1→2)-α-L-吡喃阿拉伯糖-常春藤皂苷(2),3-O-α-L-吡喃鼠李糖-(1→2)-α-L-吡喃阿拉伯糖-常春藤皂苷(3),3-O-α-L-吡喃阿拉伯糖-常春藤皂苷(4),3-O-α-L-吡喃鼠李糖-(1→2)-α-L-吡喃阿拉伯糖-28-O-β-D-吡喃葡萄糖(1→6)-β-D-吡喃葡萄糖常春藤皂苷(5),3-O-α-L-吡喃鼠李糖-(1→2)-[β-D-吡喃葡萄糖(1→4)]-α-L-吡喃阿拉伯糖-常春藤皂苷(6),3-O-α-L-吡喃鼠李糖-(1→2)[β-D-吡喃葡萄糖(1→4)]-α-L-吡喃阿拉伯糖-28-O-α-吡喃鼠李糖-(1→4)-β-D-吡喃葡萄糖(1→6)吡喃葡萄糖常春藤皂苷(7),28-O-β-D-吡喃木糖(1→3)-O-α-L-吡喃鼠李糖-(1→2)-β-D-吡喃葡萄糖(1→6)-β-D-吡喃葡萄糖阿江榄仁酸皂苷(8),28-O-α-L-吡喃鼠李糖-(1→4)-O-β-D-吡喃葡萄糖-(1→6)-O-β-D-吡喃葡萄糖去甲阿江榄仁酸皂苷(9),3-O-β-D-α-L-吡喃鼠李糖-(1→2)-α-L-吡喃阿拉伯糖-28-O-β-D-吡喃葡萄糖常春藤皂苷(10)。结论:化合物8,9为首次从该植物中分离得到,化合物10为首次从该属植物中分离得到。
Objective: To study the chemical constituents of Akebia trifoliata. Method: The compounds were separated and purified by column chromatography and their structures were established by spectroscopic methods. Result: Fifteen compounds were isolated from the extract of A. trifoliata, whose structures were determined as 3-O-β-D-glucopyranosyl ( 1 →3 ) -α-L-rhamnopyrauosyl- ( 1 →2 ) -α-L-arabiuopyranosyl hederagenin ( 1 ), 3-O-β-D-xylopyranosyl- ( 1 →2 ) -α-L-arabinopyranosyl hederagenin ( 2 ) , 3-O-α-L- rhamnopyranosyl- ( 1→2 ) -α-L-arabinopyranosyl hederagenin ( 3 ), 3-O-α-L-arabinopyranosidehederagenin ( 4 ), 3-O-α-L-rhamnopyranosyl (1→2) -α-L-arabinopyranosyl-28-O-β-D-glucopyranosyl ( 1→6 ) -β-D-glucopyranoside hederagenin ( 5 ), 3-0- ( β-D-glucopyranosyl ( 1 → 4 ) - α-L-rhamnopyranosyl- ( 1 →2 ) -α-L- arabinopyranosyl) hederagenin (6), 3-O-α-L-rhamnopyranosyl (1→2) - β-D-glucopyranosyl ( 1→4 ) -α-L- arabinopyranosyl-28-O-α-L-rhamnopy-ranosyl- ( 1 →4 ) -β-D-glucopyranosyl ( 1 →6 ) -β-D-glucopyra- nosidehederagenin ( 7 ), 28-O-β-D-xylopyranosyl- ( 1 →3 ) -O-α-L-rhamnopyranosyl- ( 1 →2 ) -β-D- glucopyranosyl ( 1 →6 ) -β-D-glucopyranoside arjunolic acid ( 8 ) , 28-O-α-L-rhamnopyranosyl- ( 1 →2 ) -β-D- glucopyranosyl (1→6) -β-D-glueopyranoside 30-no arjunolic acid (9), 3-O-α-L-rhamnopyranosyl (1→2) -α- Larabinopyranosyl-28-O-β-D-glucopyranosi-de hederagenin (10). Conclusion: Compounds 8, 9 were isolated from this plant for the first time and 10 was isolated from genus acanthopanax for the first time.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第21期56-60,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家"重大新药创制"科技重大专项(2012ZX09103201-008)
江西省科技支撑计划项目(20121BBG70019)
江西省自然科学基金项目(20122BAB205032)
关键词
预知子
化学成分
分离鉴定
Akebia trifoliata
chemical components
separation and identification