冠心平片治疗冠心病心绞痛患者33例临床观察

Clinical Observation on Guanxinping Tablet for 33 Cases of Coronary Heart Disease and Angina Pectoris

目的评价冠心平片治疗冠心病(CHD)心绞痛的临床疗效及其可能作用机制。方法 66例CHD心绞痛患者随机分为治疗组和对照组各33例,治疗组采用基础治疗联合口服冠心平片,每次1.2g,每日3次;对照组采用基础治疗联合口服心可舒片,每次1.24g,每日3次。两组均连续治疗4周。于治疗前后观察患者心绞痛发作次数和心绞痛持续时间,进行中医证候评分,检测血清内皮素(ET)和一氧化氮(NO)水平,判断心绞痛疗效、心电图疗效和综合疗效。结果治疗组心绞痛疗效、心电图疗效、综合疗效总有效率分别为87.9%、81.8%、87.9%,对照组分别为66.7%、60.6%、66.7%,治疗组各疗效均明显优于对照组(P<0.05)。治疗后治疗组患者心绞痛发作次数、持续时间及中医证候评分均较治疗前降低(P<0.05或P<0.01),并且治疗后心绞痛发作次数、中医证候评分低于对照组(P<0.05)。治疗组治疗后血浆ET水平较本组治疗前及对照组治疗后下降,NO水平升高(P<0.05或P<0.01)。结论冠心平片可改善CHD心绞痛患者的中医临床症状,缩短心绞痛发作持续时间、减少发作次数,其治疗机理可能与升高血清NO水平以及降低ET水平有关。

Objective To evaluate the efficacy and mechanism of Guanxinping Tablet [tablet for coronary heart disease （CHD）] for CHD and angina pectoris （AP）. Methods Totally 66 cases of CHD and AP were randomized into treatment group and control group, with 33 in each. Both groups were given basic treatment. The treatment group was added with 1.2 g of Guanxinping Tablet once and three times daily. The control group was added with 1.24 g of Xinkeshu Tablet once and three times daily. The medication lasted for 4 weeks in both groups. The attack frequency and duration of AP were observed before and after treatment. The TCM pattern efficacy was scored. The levels of plasma endothelin （ET） and nitric oxide （NO） were detected. The AP efficacy, electrocardiogram （ECG） efficacy and comprehensive efficacy were analyzed. Results The total effective rate of AP efficacy, ECG efficacy and comprehensive efficacy was 87.9%, 81.8% and 87.9% in the treatment group and 66.7%, 60.6% and 66.7% in the control group, with a significant difference between groups （P〈0.05）. The attack frequency and duration of AP and TCM pattern scores were significantly decreased after treatment in the treatment group （P〈 0.05 or P〈0.01）, with a significant difference between groups in the attack frequency of AP and TCM pattern scores （P〈0.05）. The ET level was significantly decreased but the NO level was significantly increased after treatment in the treatment group （P〈0.05 or P〈0.01）. There was significant difference in level of NO and ET between groups after treatment （P〈0.05）. Conclusion Guanxinping Tablet can obviously relieve the TCM symptoms, shorten the duration of AP, reduce the number of attacks and improve the clinical efficacy. Its mechanism may be relevant to increasing NO level and decreasing ET level.