血清内脂素水平与2型糖尿病患者动脉粥样硬化关系探讨

Relation between serum visfatin level and atherosclerosis in type 2 diabetes patients

目的探讨2型糖尿病患者血清内脂素水平与动脉粥样硬化的关系。方法 69例2型糖尿病患者依据有无颈动脉粥样硬化斑块分为无动脉硬化斑块组(A组)20例、动脉硬化斑块组49例,后者再根据是否伴急性脑梗死分为不伴急性脑梗死组(B组)30例和伴急性脑梗死组(C组)19例,比较各组血清内脂素水平。结果 B组、C组血清内脂素水平均高于A组(P<0.05或P<0.01)。结论内脂素可能与2型糖尿病患者动脉粥样硬化及脑梗死的发生、发展相关。

Objective To explore serum visfatin levels in type 2 diabetes patients with atherosclerosis. Methods 69 pa- tients with T2DM were divided into a control group （group A ,n = 20）, an atherosclerosis group （group B, n = 30） and an in- farction group （group C, n = 19 ）. BMI, blood pressure, blood biochemical were tested and the level of serum visfatin was meas- ured. Results The visfatin level of groups B and C was higher than that of group A （ P 〈 0.05, P 〈 0.01 ）. Conclusion The change of serum visfatin level may contribute to the pathogenesis of atherosclerosis in T2DM.