胃癌患者输注红细胞前后血清CEA、Hcy和SA水平的变化及临床意义

Changes and clinical significance of gastric cancer patients' serum CEA,Hcy and SA levels before and after transfusion of red blood cells

目的探讨胃癌患者输注红细胞前后血清癌胚抗原(CEA)、同型半胱氨酸(Hcy)和唾液酸(SA)水平的变化及临床意义。方法应用放射免疫分析法、酶联法和化学法对33例胃癌患者进行了输注红细胞治疗前后血清CEA、Hcy和SA水平测定,并与35名正常健康人作比较。结果胃癌患者在输注红细胞前血清CEA、Hcy和SA水平非常显著地高于正常人组(P<0.01),经输注红细胞2周后与正常人的比较仍有显著性差异(P<0.05)。结论检测胃癌患者输注红细胞前后血清CEA、Hcy和SA水平对其病情的发展和判断预后均具有重要的临床价值。

Objective To investigate the changes and clinical significance of gastric cancer patients＇ serum CEA, Hcy and SA levels before and after transfusion of red blood ceils. Methods Radiation immunoassay, enzyme-linked method and chemi- cal method were applied on 33 cases of patients with gastric cancer who received transfusion of red blood cells before and after treatment. Their serum levels of CEA, Hcy and SA were compared with 35 normal healthy people. Results The gastric cancer patients＇serum CEA, Hcy and SA levels before transfusion of red blood cells were significantly higher than those in the normal group （ P 〈 0.01）. Two weeks after transfusion, there was still a significant difference compared with the normal group （ P 〈 0. 05 ）. Conclusion Detection of gastric cancer patients＇serum CEA, Hcy and SA levels before and after transfusion of red blood cells has important clinical value on judgment of the disease prognosis.