职业紧张对燃煤电厂作业人群HSP70表达水平的影响

Effect of occupational stress on HSP70 expression in coal-fired power plant workers

目的检测不同职业紧张水平燃煤电厂作业人员血清中热休克蛋白70(HSP70)表达水平,探索职业紧张生理学评价指标。方法采用职业紧张量表(OSI-R)对燃煤电厂作业人员进行问卷调查,按职业紧张水平分为高、中、低水平组,并随机抽取各水平组生产人员和后勤行政管理人员各30例,测定其血清中HSP70表达水平。结果 OSI-R量表各问卷及各项目的克伦巴赫α系数均大于0.70;HSP70表达水平与PSQ得分呈正相关(P<0.05),而与ORQ和PRQ得分无明显相关性(P>0.05);作业人群、生产人员、后勤行政管理人员的各职业紧张水平组间HSP70表达水平逐级降低,差异均有统计学意义(P<0.05);生产人员的HSP70水平高于后勤行政管理人员,差异有统计学意义(P<0.05)。结论血清中HSP70表达水平可作为燃煤电厂作业人群进行职业紧张评价的重要参考指标。

Objective To assess the HSP70 level of the workers with different degree of occupational stress in a coal-fired power plant. Methods The Occupational Stress Inventory-Revised （OSI-R）, was used for questionnaire investigation, and the workers were divided into three groups according to the levels of occupational stress; the controls were came from the logistic or administrative personnels. Every group were selected 30 cases for the detection of serum HSP70 levels, respectively. Results The Cronbach alpha coefficient of the items in OSI-R were all greater than 0. 70, the HSP70 expression level was positively corre- lated with PSQ score （P 〈 0. 05）, but not correlated with ORQ and PRQ scores （P 〉 0. 05）. The levels of HSP70 among the groups with different level of occupational stress were gradually reduced （P 〈 0.05 ）, the level of HSP70 in workers was signifi- cantly higher than that of the logistic or administrative personnels （P 〈 0.05）. Conclusion The results suggest that HSP70 ser- um level may be serves as an important reference index for evaluating occupational stress in coal-fired power plant workers.