糖皮质激素非基因组机制的生理意义

Physiological Significance of Nongenomic Mechanisms of Glucocorticoids

糖皮质激素(glucocorticoids,GC)是机体应激反应中最重要的调节激素,也是临床上使用最广泛的抗炎和免疫抑制剂。GC作用除经典基因组机制外还存在非基因组机制。GC非基因组机制的临床意义特别是在大剂量应用时已比较明确,但机体这一与生俱来的重要调节机制不可能仅为外来临床用药而准备,一定有其尚未揭示的重要内在生理意义。近年来,我们以应激时GC快速分泌的积极意义为切入点,获得了系列研究结果,并结合文献回顾,提出GC非基因组机制的生理意义主要在于应激调节。

Glucocorticoids （GC） are the most importantregulatory hormonesinvolved in stress response. GCs are also widelyused clinicallyas anti-inflammatory and immunosuppressivedrugs. In addition tothe well-known classicalgenomic mechanisms, peutic benefits of nongenomic GC actions dose pulsed glucocorticoidadministration. GCs also take effects bynongenomic mechanisms. The thera- have been exploited in clinical medicine, especially with high- However, it is certainly not the case that the inherent non- genomicglucocorticoid mechanisms evolvedonly for their clinical utility. So that there must exist some un- revealedimportant physiological significance. Based onour series of studies focusing on the active actions of the rapid secreted GC overthe last few years and literaturereview, we propose that the physiological significance of nongenomic mechanisms of GC lies in stress regulation.