应激与代谢调节

Stress and Metabolic Regulation

应激是机体应对内外环境变化时所产生的以神经内分泌免疫网络活化为特征的全身性反应。越来越多的证据表明,应激条件下,高度活化的神经内分泌免疫网络对机体的代谢会产生强烈而持续的影响作用。应激对代谢的影响作用不仅局限在糖代谢、脂肪代谢和蛋白质代谢,而且对机体微量元素代谢具有重要的调控作用。持续高负荷的应激对代谢产生的负面影响超出了机体的代偿能力就会导致多种代谢性疾病的发生。

The stress is generated in response to changes in internal and external environment of the body is characterized by systemic reactions to neuroendoerine activation of the immune network. More and more evidence suggests that highly activated under stress conditions neuroendocrine immune network will have a strong and sustained influence on the body＇s metabolism. The effect of stress on the metabolism is not only confined to the glucose metabolism, fat metabolism and protein metabolism, and important role in regulating the metabolism of trace elements. Sustained high-load stress on the metabolism of the negative impact beyond the body＇s compensatory capacity will lead to a disease such as diabetes, atherosclerosis and secondary diseases.