抗真菌药物靶标及其抑制剂的研究进展

Progress on antifungal drug targets and inhibitors

目的综述抗真菌药物靶标及其抑制剂的研究进展。方法本文结合自身研究工作,分析近5年文献,总结抗真菌药物靶标及其抑制剂的最新进展。结果β-1,3-葡聚糖合成酶、羊毛甾醇14α-去甲基化酶、N-肉豆蔻酰基转移酶和分泌型天冬氨酸蛋白酶是目前研究最为集中的抗真菌药靶,其抑制剂显示了良好的新药开发前景。结论优化现有药物化学结构和发现全新作用机制的先导化合物,对研发新一代抗真菌药物具有重要意义。

Objective To review recent progress of antifungal drug targets and their inhibitors. Methods Literatures in re- cent five years were analyzed in combination of the authors＇own research work and recent developments of antifungal targets and inhibi- tors were summarized. Results Current research focused on lanosterol 14-demethylase, β-1,3-gluean synthasc, N-myristoyltransferase and secreted aspartic protease. The inhibitors of these targets showed promising future for the development of new antifungal drugs. Conclusion Optimizing the chemical structures of current antifungal agents and discover lead compounds with novel mode of action are of great importance to develop new generation of antifungal agents.