脐血维生素D与婴儿维生素D水平的相关性分析

Vitamin D levels in cord blood of newborn and in blood of infant:a correlation study

目的了解新生儿脐血维生素D与婴儿维生素D水平及其相关性。方法收集340名新生儿脐血及与其配对的9个月婴儿血,采用酶联免疫法检测新生儿脐血及婴儿血的血清25-(OH)D水平。通过问卷调查收集婴儿喂养方式、母乳喂养的时间、添加维生素D的时间、剂量、户外活动时间等资料;并采用直线相关分析、单因素方差分析及χ2检验等进行新生儿脐血与婴儿血清维生素D水平相关性分析等。结果新生儿脐血和婴儿的25-(OH)D水平分别是(30.03±11.24)nmol/L、(79.05±28.96)nmol/L;92.94%的新生儿和9.71%的9个月婴儿的25-(OH)D水平低于50nmol/L,33.82%的新生儿25-(OH)D水平低于25nmol/L,9个月婴儿的25-(OH)D水平无一例低于25nmol/L。新生儿脐血与9个月婴儿血清25-(OH)D水平无相关性,spearman相关系数r=0.036,P=0.504。新生儿脐血及9个月婴儿血清的25-(OH)D水平均存在明显季节性差异(F分别=20.845,3.565;P分别为0.000,0.014)。维生素D水平在秋季最高,春季最低。结论新生儿脐血维生素D缺乏或不足普遍存在,尤其在春季。婴儿维生素D水平相对较高,尤其是在秋季。新生儿脐血与9个月婴儿血清25-(OH)D水平无相关性。提示婴幼儿维生素D缺乏可防可控,只要合理及时的补充维生素D,即可以有效的预防。必须加强妇幼保健工作管理,重视孕期维生素D的补充;冬春季节的孕妇(尤其是孕晚期)和新生儿以及婴儿应该多参加户外活动,特别重视维生素D的补充。

Objective To address the correlation between vitamin D levels in neonatal cord blood and in blood of infant. Methods A total of 340 newborn cord blood samples and blood samples from infants aged 9 months were collected and measured for serum 25 - （OH） D level by ELISA. Mothers were surveyed in terms of feed ing methods, breastfeeding period, vitamin D intake and outdoor activity. The linear correlation analysis, one-way ANOVA and ehi-square test were applied to analyze the correlation between neonatal cord blood vita- min D level and vitamin D level in blood of infant. Results The average serum levels of 25 - （OH） D in cord blood and in blood of infants were 30.03~11.24 nmol / L and 79.05_＋28.96 nmol / L. 92.94o/oo newbo rns and 9.71~/00 infants had serum 25 - （OH） D level lower than 50nmol / L, and 33.82% newborns and none of infants had serum 25 - （OH） D level lower than 25 nmol / L. There was no correlation found between ser- um 25 - （OH） D levels in neonatal cord blood and in blood of infant （ spearman correlation coefficient r=0. 036, P=0. 504） . Moreover, serum 25 - （OH） D levels in both blood samples fluctuated seasonally with the highest in fall and the lowest in spring （F=20. 845, 3. 565, P=0. 000, 0. 014）. Conclusions Vitamin D deficiency is common in newborn, especially in spring. However, vitamin D level in infants is relatively high. Therefore, there was no correlation between neonatal cord blood vitamin D level and vitamin D level in the blood of nine months infant, indicating that. vitamin D deficiency in infants is avoidable and controllable by timely supplementing vitamin D.