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首发未经治疗精神分裂症患者认知功能与血清脑源性神经营养因子的关系 被引量:7

The relationship between cognition and brain-derived neurophic factor in patients with first-episode schizophrenia
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摘要 目的探讨精神分裂症认知损害特点及其与血清脑源性神经营养因子(BDNF)的关系。方法对34例首发未经治疗精神分裂症患者(患者组),33名健康者(对照组)采用数字符号编码及符号搜索测验、连线测验、色字词测验、韦氏记忆测验、威斯康辛卡片分类测验和酶联免疫吸附法进行认知功能评定和血清BDNF浓度的检测。结果 (1)各项测验中,除连线A错误数[(0.58±1.15)vs(0.15±0.71),t=1.85,P=0.068]、符号搜索错误数[(2.41±3.61)vs(1.48±1.95),t=1.31,P=0.19]指标之外,患者组的成绩均差于对照组。(2)患者组血清BDNF浓度低于对照组[(2.43±1.58)μg/Lvs(3.96±2.28)μg/L,t=-3.18,P=0.002]。(3)患者组认知缺陷与血清BDNF水平之间无相关性。结论精神分裂症患者存在广泛认知损害和BDNF降低;精神分裂症认知损害与血清BDNF关系不大。 Objective To assess the relationship between cognition and brain derived neurotrophic factor (BD- NF) in patients with first-episode schizophrenia. Methods 34 patients with first-episode schizophrenia and 33 healthy controls were enrolled into the study. Their cognition ability was assessed by using a battery of neu- ropsychologieal test, which included Trail making test,, Stroop test, Symbol coding, Symbol search, Wis- consin card sorting test and Wechsler memory scale. Serum BDNF level was determined by ELISA. Results Compared with healthy controls, patients with first-episode schizophrenia had lower scores in all tests except the errors in the symbol search ((2.41±3.61) vs (1. 48±1.95), t=1.31, P=0.19] and the errors in Trail making test A [ (0.58±1.15) vs (0.15±0.71), t=1.85, P=0.068] .The serum BDNFlevel was lower in patients with first-episode schizophrenia than that in healthy controls [ (2.43±1.58) ug/L vs. (3.96±2.28) ug/L t=-3. 18, P=0. 002] . The impaired cognition of patients was not related to serum BDNF lev- el. Conclusions Although cognitive impairment and low BDNF level are noticed in patients with first-episode schizophrenia, the two are not closely related.
出处 《中国预防医学杂志》 CAS 2013年第10期741-744,共4页 Chinese Preventive Medicine
基金 2009年广东省自然科学基金资助项目(9151008901000027)
关键词 首发未经治疗精神分裂症 认知功能 血清脑源性神经营养因子 Patient First-episode schizophrenia Cognition BDNF
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参考文献15

  • 1Heaton RK, Gladsjo TA, Palmer BW, et al. Stability and course of neuropsychological deficits in schizophrenia[J]. Arch Gen Psychiatry, 2001, 58 (1): 24-32.
  • 2Cao G, Pei W, Ge H, etal. In vivo delivery of a Bcl xL fusion protein containing the TAT protein transduetion do- main protects against isehemic brain injury and neuronal ap- optosis[J].J Neurosci, 2002, 22 (13): 5423- 5431.
  • 3Martinotti G, Dilorio G, Marini S, etal. Nerve growth factor and brain-derived neurophic factor concentrations in schizophrenia= a review[J]. J Biol Requl Homeost Agents, 2012, 26 (3): 347- 56.
  • 4Pillai A, Kale A, Joshi S, etal. Decreased BDNF levels in CSF of drug naive first-episode psychotic sbujects: correla- tion with plasma BDNF and psychopathology [J]. Int J Neu- ropsychopharmacol, 2010, 13 (4): 535-539.
  • 5陈大春,李艳丽,修梅红,王宁,杨可冰,聂鹰,卞清涛,张向阳.利培酮治疗首发精神分裂症患者血清脑源性神经营养因子的变化及其与临床疗效和认知功能的关系[J].中国神经精神疾病杂志,2010,36(9):529-532. 被引量:34
  • 6Shimizu E , Hashimoto K , Watanabe H , et al. Serum brain-derived neurotrophic factor (BDNF) levels in schizo- phrenia are indistinguishable from controls [J]. Neurosci Lett, 2003, 351 (2): 111- 114.
  • 7钟杰,聂晶.强迫症患者的执行功能研究[J].中国临床心理学杂志,2004,12(4):420-423. 被引量:21
  • 8张文顺,吴东辉,高北陵,郭金宏,刘奋,刘哲宁.发作期精神分裂症患者执行功能及注意功能的对照研究[J].精神医学杂志,2009,22(5):360-362. 被引量:5
  • 9盛建华,宋振华,施慎逊,袁一萍.精神分裂症的记忆功能及其影响因素[J].精神医学杂志,2007,20(3):132-134. 被引量:15
  • 10汤慈美.神经病学,第7卷,神经心理学[M].北京:人民军医出版社,2001:236-327.

二级参考文献94

  • 1朱春燕,汪凯,Lee TMC.执行功能与精神分裂症[J].心理科学进展,2004,12(5):743-751. 被引量:25
  • 2安宝富,李晏,王长虹.首发偏执型精神分裂症患者执行功能研究[J].中国行为医学科学,2006,15(4):340-341. 被引量:18
  • 3龚耀先.修订韦氏记忆量表手册[M].长沙:湖南医科大学,1989.1.
  • 4Funahashi S. Neuronal mechanisms of executive control by the prefrontal cortex[ J]. Neuroscience Research, 2001 , 39 : 147 - 165.
  • 5Bergera A, Posner M I. Pathologies of brain attentional networks[ J ]. Neuroscience and Biobehavioral Reviews, 2000, 24:3 -5.
  • 6Hugdahi K, Rund B R, Lund A, et al. Attentional and Executive Dysfunctions in Schizophrenia and Depression: Evidence from Diehotic Listening Performance [ J ]. Society of Biological Psychiatry, 2003, 53:609 -616.
  • 7Zakzanis K K. Neuropsychological correlates of positive vs. negative schizophrenic symptomatology[ J]. Schizophrenia Research, 1998,29:227 -233.
  • 8Lysaker P H, Bryson G J, Lancaster R S, et al. Insight in schizophrenia: associations with executive function and coping style [ J ]. Schizophrenia Research, 2002, 59 : 41 - 47.
  • 9Liu S K, Chen W J, Chang C J, et al. Effects of Atypical Neuroleptics on Sustained Attention Deficits in Schizophrenia: A Trial of Risperidone Versus Haloperidol [ J ]. Neuropsychopharmacology, 2000, 22 : 311 - 319.
  • 10DoUfus S, Lombardo C, Benali K, et al. Executive/attentional cognitive functions in schizophrenic patients and their parents: apreliminary study [ J ]. Schizophrenia Research, 2002, 53 : 93 - 99.

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