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碱性磷酸酶在慢性肾脏病患者中的应用 被引量：7

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摘要 矿物质和骨异常（mineral and bone disorder,MBD）是慢性肾脏病（chronic kidney disease,CKD）患者常见的并发症,与CKD患者骨折、心血管事件和心血管死亡率明显相关。以往MBD的治疗主要聚焦在CKD患者中继发性甲状旁腺功能亢进症（secondary hyperparathyroidism,SHPT）、活性维生素D的缺乏和体内磷的潴留。近年来,无力型骨病的发生率逐渐增多,对其的诊断和治疗受到重视。
作者 陈孜瑾 陈晓农
机构地区 上海交通大学医学院附属瑞金医院肾脏科
出处 《中国血液净化》 2013年第10期525-527,共3页 Chinese Journal of Blood Purification
基金 上海市科委医学引导项目(114119b2700)
关键词 慢性肾脏病 碱性磷酸酶 患者 继发性甲状旁腺功能亢进症 应用 心血管死亡率 活性维生素D 心血管事件
分类号 R692.5 [医药卫生—泌尿科学]
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参考文献13

  • 1KDIGO clinical practice guideline for the diagno- sis, evaluation, prevention, and treatment of Chronic Kidney Disease- Mineral and Bone Disorder (CKD-MBD)[J]. Kidney Int, 2009(Suppl):Sl-130.
  • 2Magnusson P, Sharp CA, Magnusson M, et al. Effect of chronic renal failure on bone turnover and bone alkaline phosphatase isoforms[J]. Kidney Int, 2001, 60:257-265.
  • 3Haarhaus M, Fernstrom A, Magnusson M, et al. Clini- cal significance of bone alkaline phosphatase iso- forms, including the novel Blx isoform, in mild to moderate chronic kidney disease[J]. Nephrol, Dial, Transplant, 2009, 24:3382-3389.
  • 4Archer FJ, Taylor SM. Alkaline phosphatase bone isoenzyme and osteocalcin in the serum of hyperthy- roid cats[J]. Cana Veterin J, 1996, 37:735-739.
  • 5Urena P, Hruby M, Ferreira A, et al. Plasma total versus bone alkaline phosphatase as markers of bone turnover in hemodialysis patients[J]. J Ame Soc Nephrol, 1996, 7:506-512.
  • 6Fletcher S, Jones RG, Rayner HC, et al. Assessment of renal esteodystrophy in dialysis patients: use of bone alkaline phosphatase, bone mineral density and parathyroid ultrasound in comparison with bone histology[J]. Nephron, 1997, 75:412-419.
  • 7陈孜瑾,陈晓农,马晓波,侯亮,丁蓓,凌华威,李晓,任红,陈楠.应用腰椎侧位片评价血液透析患者腹主动脉钙化[J].中华肾脏病杂志,2012,28(8):606-610. 被引量：13
  • 8Noordzij M, Cranenburg EM, Engelsman LF, et al. Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients[J]. Nepbrol, Dial, Transplant, 2011, 26:1662-1669.
  • 9Lomashvili KA, Garg P, Narisawa S, et al. Upregula- tion of alkaline phosphatase and pyrophosphate hy- drolysis: potential mechanism for uremic vascular calcification[J]. Kidney Int, 2008, 73:1024-i030.
  • 10Regidor DL, Kovesdy CP, Mehrotra R, et al. Serum alkaline phosphatase predicts mortality among main- tenance hemodialysis patients[J]. J Am Soc Nephrol, 2008, 19:2193-2203.

二级参考文献15

  • 1Witteman JC, Kok F J, van Saase JL, et al. Aortic calcification as a predictor of cardiovascular mortality. Lancet, 1986, 2(8516): 1120-1122.
  • 2Kauppila LI, Polak JF, Cupples LA, et al. New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis, 1997, 132: 245-250.
  • 3Toussaint ND, Pedagogos E, Lau KK, et al. Lateral lumbar X-ray assessment of abdominal aortic calcification inAustralian haemodialysis patients. Nephrology, 2011, 16: 389-395.
  • 4Okuno S, Ishimura E, Kitatani K, et al. Presence of abdominal aortic calcification is significantly associated with all-cause and cardiovascular mortality in maintenance hemodialysis patients. Am J Kidney Dis, 2007, 49: 417- 425.
  • 5Honkanen E, Kauppila L, Wikstr6m B, et al. Abdominal aortic calcification in dialysis patients: results of the CORD study. Nephrol Dial Transplant, 2008, 23: 4009-4015.
  • 6Qunibi WY. Reducing the burden of cardiovascular calcification in patients with chronic kidney disease. J Am Soc Nephrol, 2005, 16: 95-102.
  • 7Allison MA, Criqui MH, Wright CM. Patterns and risk factors for systemic calcified atherosclerosis. Arterioscler Thromb Vasc Biol, 2004, 24: 331-336.
  • 8Moe SM, O'Neill KD, Fineberg N, et al. Assessment of vascular calcification in ESRD patients using spiral CT. Nephrol Dial Transplant, 2003, 18: 1152-1158.
  • 9Moe SM, O'Neill KD, Reslerova M, et al. Natural history of vascular calcification in dialysis and transplant patients. Nephrol Dial Transplant, 2004, 19: 2387-2393.
  • 10London GM, Gu6rin AP, Marchais SJ, et al. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant, 2003, 18: 1731-1740.

共引文献12

同被引文献46

引证文献7

二级引证文献36

中国血液净化
2013年 第10期

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