LASS2在乳腺癌中的表达及其与患者预后的关系

Expression of LASS2 in Breast Carcinoma and Its Correlation with the Prognosis

【目的】探讨人源性长寿保障基因2（LASS2）在乳腺癌中的表达与临床病理因素及预后的关系。【方法】采用免疫组化检测乳腺癌及乳腺良性疾病的LASS2的蛋白表达，采用实时定量Q-PCR检测LASS2mRNA的表达情况，分析与临床病理因素的关系，并完成术后的长期随访。【结果]LASS2mRNA和其蛋白表达与患者的淋巴结转移，肿瘤分期密切相关（P〈0．05），而与患者的年龄，肿瘤的大小，肿瘤的分级及肿瘤的类型无关（P〉0．05），且LASS2表达阳性患者的总生存期及无病生成期都明显高于阴性患者（P〈0．05），多因素COX分析提示LASS2是患者的一个独立的预后因素。【结论】LASs2在乳腺癌的疾病进展中起到非常重的作用，是分析乳腺癌患者的一个预后指标。

Objective To explore the relationship between the expression of LASS2 gene in breast cancer and clinical pathological factors. [Methods The protein expression of LASS2 in breast cancer and benign breast disease was detected immunohistochemical method. Real-time quantitive PCR was used to examine the expression of LASS2 mRNA. The correlation with clinical pathological factors was analyzed. Long-tern post- operative follow up was completed. [Results] The expression of LASS2 mRNA and protein was closely corre- lated with lymph node metastasis and tumor stage（ P d0. 05）, but not associated with the age, tumor size, tumor grade and histological type（ P 〉0. 05）. The overall survival and disease-free survival of patients with positive expression of LASS2 were obviously higher than those of patients with negative expression of LASS2 （ P 〈0.05）. Multifactor COX analysis indicated that LASS2 was an independent factor for the prognosis. [Conclusion] LASS2 plays very important role in the progression of breast cancer. It is a prognostic indicator of patients with breast cancer.