黛力新联合曲美布丁、雷贝拉唑治疗功能性消化不良疗效观察

Observation of the Efficacy of the Combination with Deanxit for the Treatment of Functional Dyspepsia

【目的】探讨黛力新联合曲美布丁、雷贝拉唑治疗功能性消化不良的疗效。【方法】符合罗马Ⅲ功能性消化不良诊断标准的伴有焦虑及抑郁状态的患者120例随机分为观察组60例和对照组60例。对照组根据个体化原则给予促动力药物＋促消化药物（马来酸曲关布丁＋复方阿嗪米特）和（或）质子泵抑制剂（雷贝拉唑），观察组在对照组的基础上加用黛力新联合治疗。两组疗程均4周。每例患者在治疗前后均详细填写临床疗效观察表及汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA），并计算总有效率。【结果】观察组治疗后症状积分（i．80±0．91）分、HAMD积分（13．45±4．24）分和HAMA积分（1i．25±2．14）分，下降均较对照组[分别为（5．52±1．40）分，（20．52±6．40）分，（18．72±4．30）分]更明显（P〈0．05）。对照组治疗总有效率73．33％；观察组治疗总有效率93．33％，二者有统计学差异（P〈O．05）。【结论】黛力新联合曲美布丁、雷贝拉唑，可显著提高治疗功能性消化不良的疗效，不良反应少，可在临床应用推广。

[Objective] To observe the efficacy of the combination with Deanxit for the treatment of func- tional dyspepsia. [Methods]Totally 120 patients with functional dyspepsia according with Rome III diagnostic standard and anxious as well as depressive state were randomly divided into treatment group（n=60） and con- trol group（n=60）. According to the principle of individualization, the control group was treated with proki- netic drug, digestion drug（trimebutine maleate and compound azintamide） and/or proton pump inhibitor（rabe- prazole）, while the treatment group was additionally treated with Deanxit based on the treatment of the control group. Both groups were treated for 4 weeks. Each patient filled clinical curative effect observation table, Hamilton depression scale（HAMD） and Hamilton anxiety scale（HAMA） before and after treatment. Total ef- fective rate was calculated. [Results] Compared with control group, the symptom score, HAMD and HAMA scores in treatment group after treatment decreased more significantly[（1. 80 ± 0. 91） vs （5. 52 ± 1. 40）, （13.45±4.24） vs （20.52±6.40）, （11.25±2.14） vs （18.72±4.30）]（ P 〈0.05）. The overall effective rate of control group and treatment group was 73.33% and 93.33% respectively, and there was significant differ- ence（ P 〈0.05）. [Conclusion] Compared with single use of prokinetic drug, digestion drug and/or proton pump inhibitor, the combination of Deanxit for the treatment of functional dyspepsia can significantly improve the efficacy with less adverse reaction, so it can be recommended to use in clinical practice.