莫沙必利与多潘立酮治疗餐后不适综合征临床疗效比较

Comparison of clinical curative effects between mosapride and domperidone in treating postprandial discomfort syndrome

目的比较莫沙必利与多潘立酮治疗餐后不适综合征(PDS)的疗效。方法将58例符合罗马ⅢPDS诊断标准的患者按入院先后半随机分为A组30例(莫沙必利片剂5 mg,3次/d,餐前服用),B组28例(多潘立酮片10 mg,3次/d,餐前服用),疗程28 d。疗程结束后观察对比两种药物的疗效及不良反应。结果A组的总有效率为93.3%,B组总有效率为67.9%,两组比较差异有统计学意义(P<0.05)。两组药物不良反应轻微。结论莫沙必利与多潘立酮治疗PDS疗效均较好,不良反应轻微,但总体疗效以莫沙必利为佳。

Objective To compare the therapeutic effects between mosapride and domperidone in the treat- ment of postprandial discomfort syndrome （PDS）. Methods Fifty-eight eases of PDS according to Rome m PDS diag- nostic criteria were randomly assigned into two groups according to admission order. In the A group,30 cases patients were treated with mosapride tablets ：5 mg 3 times daily, taken before meals, in the B group, 28 patients were treated with domperidone tablets ： 10 mg, 3 times daily, taken before meals, the course were 28 days. After the end of treat- ment, the efficacy and adverse drug reaction were compared between two groups. Results The total effective rate in the A group was 93.3% and the total effective rate in the B group was 67.9%. There was a statistically significant difference in total effective rate between two groups （ P 〈 0. 05 ）. There was minor adverse drug reactions in two groups. Conclusion The therapeutic effects of mosapride and domperidone in treating PDS are good with minor ad- verse reactions. But mosapride is superior to domperidone in the total effective rate.