冠心病患者B-型尿钠肽与超敏C反应蛋白 肌红蛋白的检测及其临床价值

Relationship between BNP,hs-CRP and MYO in coronary heart disease and its clinical value

目的观察B-型尿钠肽(BNP)与超敏C反应蛋白(hs-CRP)、肌红蛋白(MYO)在冠心病中的变化情况并分析其相关性,评价其在冠心病诊疗方面的价值。方法测定20例稳定型心绞痛(SA)、46例不稳定型心绞痛(UA)、22例急性心肌梗死(AMI)、28例非冠心病(NS)患者全血BNP与HS-CRP、MYO的浓度变化情况,并进行统计学分析。结果 BNP与hs-CRP在AMI组明显升高,SA和UA组次之,MYO在AMI组升高最明显,而SA组和UA组两组间比较无统计学差异,但较对照组有统计学差异。结论冠心病患者BNP与hs-CRP、MYO正相关,3者显著升高可辅助临床诊断急性心梗,BNP与hs-CRP升高可以鉴别SA和UA。

Objective To observe the changes of blood secretary B-type natriuretic peptide（BNP） ,high sensi-tive C-reactive protein（hs-CRP） and myoglobin（MYO） ,in patients with coronary heart disease and to analyze their correlation .Methods Blood levels of BNP ,hs-CRP and MYO were detected in 20 patients with stable angina（SA） , 46 patients with unstable angina（UA） ,22 patients with acute myocardial infarction（AMI） and 28 patients with nor-mal coronary artery（NS） .Results Blood levels of BNP and hs-CRP increased significantly in AMI group compared with those in SA and UA groups .MYO increased statistical significant difference between them .Conclusion BNP , hs-CRP and MYO present positive correlation .The obviously increasing of BNP ,hs-CRP and MYO is useful for the diagnosis of AMI ,and the increasing of BNP and HS-CRP is useful to distinguish SA and UA .