美沙酮替代疗法患者体液免疫变化的研究

Influence of methadone substitution therapy on humoral immunity

目的探讨海洛因依赖者经美沙酮替代疗法后体液免疫功能变化的状况,以期指导临床治疗。方法将200例美沙酮替代疗法患者设为实验组,100例健康体检者设为对照组,比较实验组治疗半年前后,其体液免疫各指标(IgG、IgA、IgM、C3、C4)的差异;同时比较实验组治疗前后与对照组体液免疫各指标的差异。结果海洛因依赖者治疗前与对照组比较IgG、IgA、IgM均明显升高(P<0.01),补体C3、C4均明显下降(P<0.01);经美沙酮替代疗法治疗后与治疗前比较,IgG、IgA、IgM均明显下降(P<0.01),补体C3、C4均明显升高(P<0.01);治疗后与对照组比较,IgA、C3、C4差异无统计学意义(P>0.05),IgG、IgM差异仍有统计学意义(P<0.01)。结论对美沙酮替代疗法患者进行体液免疫指标的定期检测具有重要的临床指导意义。

Objective To analyze the influence of methadone substitution treatment on humoral immunity in heroin addicts .Methods IgG ,IgA ,IgM ,C3 and C4 levels were detected in 200 heroin addicts before and after metha-done substitution treatment ,and 100 healthy subjects were enrolled and control group .Results Levels of IgG ,IgA and IgM were higher ,but those of C3 and C4 were lower in heroin addicts before treatment than healthy subjects （P0 .05） ,but the difference of IgG and IgM were still with significance （P〈0 .01） .Conclusion Monitoring of humoral immunity could be with great significance in heroin addicts receiving methadone substitution treatment .