白细胞介素-18在全身型幼年特发性关节炎并发巨噬细胞活化综合征的诊断意义

Significance of IL-18 in diagnosis of macrophage activation syndrome due to systemic-onset juvenile idiopathic arthritis

目的探讨白细胞介素-18(IL-18)在全身型幼年特发性关节炎(SoJIA)合并巨噬细胞活化综合征(MAS)中的早期诊断意义。方法用酶联免疫吸附(ELISA)测定方法检测SoJIA并MAS组、活动性SoJIA组、幼年特发性关节炎(JIA)其他亚型组及正常儿童血清中的IL-18水平。结果 4组研究对象中SoJIA合并MAS患儿血清IL-18的表达最高,活动性SoJIA组次之,健康对照组血清IL-18的表达最低,各组间差异有统计学意义。结论 SoJIA合并MAS患者血清IL-18表达明显增高,检测患者血清IL-18水平有助于早期诊断MAS。

Objective To investigate the significance of IL-18in diagnosis of macrophage activation syndrome（MAS）due to systemic-onset juvenile idiopathic arthritis（SoJIA）.Methods Concentrations of IL-18were quantified in serum of the four groups（patients with MAS complicating SoJIA,patients with SoJIA,patients with JIA but not SoJIA and controls）by ELISA.Results Serum IL-18concentrations of MAS complicating SoJIA patients are significantly higher than those of any other patients in the study,SoJIA patients are the second high in the four groups,and the IL-18concentrations in controls are the lowest.Conclusion IL-18may be important in the diagnosis of MAS complicating SoJIA.