期刊文献+

低密度脂蛋白受体、脂蛋白脂酶基因多态性在缺血性脑血管病发病机制中作用的研究进展 被引量:3

下载PDF
导出
摘要 缺血性脑血管病(ICVD)是一种复杂得多因素疾病,高发病率和高病死率是其突出特征。有研究显示,高三酰甘油和胆固醇水平、高血压、糖尿病、吸烟、饮酒和药物滥用是临床上引发缺血性脑血管病的危险因素[1,2]。有研究进一步显示,遗传背景和缺血性脑血管病的发生密切相关[3]。缺血性脑血管病主要包括短暂性脑缺血发作和脑梗死。脑梗死包括动脉粥样硬化性血栓性脑梗死、
出处 《国际检验医学杂志》 CAS 2013年第20期2716-2718,共3页 International Journal of Laboratory Medicine
  • 相关文献

参考文献23

  • 1Elias MF, Sullivan LM, D'Agostino RB, et al. Framingham stroke risk profile and lowered cognitive performance[J]. Stroke, 2004, 35(2) :404-409.
  • 2Lipska K, Sylaja PN, Sarma PS, et al. Risk factors for acute ischaemic stroke in young adults in South India[J]. J Neurol Neuro surg Psychiatry, 2007,78(9): 959 963.
  • 3Dichgans M. Genetics of ischaemic stroke[J]. Lancet Neurol, 2007,6(2) :149-161.
  • 4Markaki I,Franzen I,Talani C, et al. Lonterm survival of ischemic cerebrovascular disease in the acute inflammatory stroke study,a hospital-based cohort described by TOAST and ASCO. [J]. Cerebrovasc,Dis,2013,35(3) -213-219.
  • 5Lee JD,Lin YH, Huang YC, et al. Genetic polymorphisms of low density lipoprotein receptor can modify stroke presentation[J]. Neurol Res,2010,32(5):535-540.
  • 6Hu LH,Zhang T, Shao Q, et al. Atorvastatin suppresses oxidized LDL-induced dendritic ceil-like differentiation of RAW264.7 cells regulated by the p38 MAPK pathway[J]. Mol Cell Bioehem, 2012,371(1/2) :105-113.
  • 7Chahil JK, Lye SH, Bagali PG, et al. A novel pathogenic variant of the LDLR gene in the Asian population and its clinical correlation with familial hypercholesterolemia[J]. Mol Biol Rep,2012,39(7) :7831-7838.
  • 8刘爱萍,詹思延,李立明.低密度脂蛋白受体基因多态性与血脂、肥胖及高血压的关系[J].中华流行病学杂志,2000,21(6):460-462. 被引量:4
  • 9Frikke-Schmidt R, Nordestgaard BG, Sehnohr P, et al. Single no cleotide polymorphism in the low-density lipoprotein receptor is associated with a threefold risk of stroke. A case-control and pro spective study[J]. Eur Heart,2004,25(11) :943 951.
  • 10Bovenschen N, Herz J,Grimbergen JM, et al. Elevated plasma factor Ⅷ in a mouse model of low density lipoprotein receptor-related protein deficiency[J]. Blood, 2003,101 (10) : 3933 3939.

二级参考文献2

共引文献3

同被引文献32

  • 1丙型肝炎防治指南[J].中华内科杂志,2004,43(7):551-555. 被引量:106
  • 2李晗,刘正稳,韩群英,李雁.低密度脂蛋白受体基因多态性及其与慢性丙型肝炎的相关性[J].中国药物与临床,2006,6(2):88-91. 被引量:3
  • 3Wang H,Eckel RH.Lipoprotein lipase in the brain and nervous system[J].Annu Rev Nutr,2012,21(32):147-160.
  • 4Munshi A,Babu MS,Kaul S,et al.Association of LPL gene variant and LDL,HDL,VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes[J].J Neurol Sci,2012,318(1/2):51-54.
  • 5Davies BS,Beigneux AP,Fong LG,et al.New wrinkles in lipoprotein lipase biology[J].Curr Opin Lipidol,2012,23(1):35-42.
  • 6Shimo-Nakanishi Y,Urabe T,Hattori N,et al.Polymorphism of the lipoprotein lipase gene and risk of atherothrombotic cerebral infarction in the Japanese[J].Stroke,2001,32(7):1481-1486.
  • 7Wang C,Sun T,Li H,et al.Lipoprotein lipase Ser447Ter polymorphism associated with the risk of ischemic stroke:a meta-analysis[J].Thromb Res,2011,128(5):107-112.
  • 8Baum L,Ng HK,Wong KS,et al.Associations of apolipoprotein E exon 4and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction[J].Clin Chem Lab Med,2006,44(3):274-281.
  • 9Morrison AC,Ballantyne CM,Bray M,et al.LPL polymorphism predicts stroke risk in men[J].Genet Epidemiol.2002,22(3):233-242.
  • 10Mychykangas L,Polikoski T,Sulkava R,et al.Association of lipoprotein lipase Ser447Ter polymorphism with brain infarction:apopulation-based neuropathological study[J].Ann Med,2001,33(7):486-492.

引证文献3

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部