合并慢性阻塞性肺疾病的社区获得性肺炎患者常见细菌及耐药性分析

Community-acquired Pneumonia Bacteriology Antibiotic Resistance Analysis of Patients with COPD

目的:了解合并慢性阻塞性肺疾病(COPD)的社区获得性肺炎患者常见病原菌及耐药性情况,为临床治疗提供参考。方法:对我院108例合并慢性阻塞性肺疾病(COPD)的社区获得性肺炎患者的合格痰标本进行痰培养及药敏试验,对结果进行统计。结果:108例患者痰培养阳性者共有50例,共获得致病菌株53株,革兰阴性杆菌占56.6%,其中肺炎克雷伯菌最多(18.9%),其次为铜绿假单胞菌(15.1%)、大肠埃希菌(9.4%)。革兰阳性球菌以金黄色葡萄球菌最多(17.0%),其次为肺炎链球菌(11.3%),溶血性链球菌(7.5%)。大多数病原菌存在多重耐药。结论:合并慢性阻塞性肺疾病(COPD)的社区获得性肺炎患者常见致病菌以革兰阴性杆菌多见,且耐药严重,应引起临床足够重视。

Objective To investigate the distribution and resis- tance to antibiotics of patients of community acquired pneumonia with chronic obstructive pulmonary disease. Methods 108 admitted patients of community acquired pneumonia with chronic obstructive pulmonary disease who were hospitalized in our hospital, Character- istics of bacteriology and drug resistance were analyzed. Results 53 strains were identified from 108 sputum ： 56.4 % was Gram-negative bacilli, 44.6% Gram-positive cocci, the outstanding bacteria are Klebsiella pneumonia （18.9%） and Staphylococcus aureus （17. 0% ）. Most of pathogenic bacteria exist multiple drug resistance. Conclusion The main isolated bacteria from patients of community acquired pneumonia with chronic obstructive pulmonary disease are Gram-negative bacteria, and antimicrobial resistance is very com- mon.