蕲蛇酶治疗急性脑梗死50例临床观察

Conservation of 50 Patients by Using Acutase Injection Treat Acute Cerebral Infarction

目的 观察蕲蛇酶治疗急性脑梗死的临床效果。 方法 将 95例急性脑梗死患者随机分治疗组和对照组。治疗组 50例 ,予蕲蛇酶 0 .75u加入生理盐水 2 50 ml中静脉滴注 ,每日 1次 ,7天 1疗程 ,停药5天后进行第 2疗程。对照组 4 5例 ,予低分子右旋糖酐 50 0 ml加川芎嗪 0 .1 g静脉滴注 ,每日 1次 ,7天1疗程 ,停药 5天后进行第 2疗程 ,两组均常规应用 2 0 %甘露醇和尼莫地平等。 2个疗程结束后进行疗效评估。 结果 治疗组基本治愈 2 4例 ,显著进步 1 8例 ,有效率 (基本治愈十显著进步 ) 84 %。对照组基本治愈 1 3例 ,显著进步 1 5例 ,有效率 62 .2 %。两组比较有显著性差异 ( P <0 .0 5)。蕲蛇酶能显著降低血小板、全血粘度、血浆粘度、纤维蛋白原 ,用药前后比较差异极显著 ( P <0 .0 1 )。 结论 蕲蛇酶具有溶解血栓及降低血液粘滞度作用 ,疗效确切 ,副作用少 ,值得临床推广。

Objective To observate the treated effect Chinas for acute cerebral infarction patients using Acutase injection treating. Methods Divide the 95 patients acute cerbral infarction patients into treat group and contrast group.Treat group:Add Acutase injection 0.75u to 250ml N.S dropinto veins every day.The treatcourse is seven days,affter five days to begin the second treat.Contrast group:Add liqastrazine 100mg to 500ml Dextran 40 drpinto veins every day,treat contimed seven days,after five days to begin the second treat.Both groups using 20% mannitol and Nimodipine Normally distinguish the effect after two treated. Results Treat group 24 patients were cured and 18 case had a great inprovemaent,cure rate is 84%,contrast group 13 case were cured and 15 patients had a apparent improvemeat,cure rate is 62.2%.The cure rate of treat group is apparent higher than contrast group's(P<0.05).Acutase injection can decrease thrombocyte density Blood's riscosity.Plasmas's viscosity and fibrin's density.There is a very different after treating(P<0.01). Conclusion Acutase injection can pyknosis thrombosis and decrease the Blood's viscosity. [