降纤酶治疗急性脑梗死双盲对照研究

Study of A Double-blinded Control Trial in Treating Acute Cerebral Infarction with Defibrase

目的 观察降纤酶治疗急性脑梗死的临床疗效。方法 用国产双盲编号的降纤酶静滴治疗发病2 4 h内的急性脑梗死患者 65例 (治疗组 31例、对照组 34例 ) ,并同时于治疗前、后进行神经功能缺损评分及检测血浆纤维蛋白原 ( FG)、凝血酶原时间 ( PT)、凝血酶原活动度 ( PA)。结果 神经功能缺损评分显著进步率 ,降纤酶治疗组 74 .2 % ,明显优于对照组的 2 9.2 % ,两组比较有显著性差异 ( P <0 .0 0 1 ) ;治疗组 FG降低明显优于对照组 ( P <0 .0 0 1 )。结论 降纤酶治疗急性脑梗死有效 ,与降低血浆纤维蛋白原明显相关。

Objective To study the effect of defibrase in treating acute cerebral infarction,65 patient. Method We evaluated the neurological deficiency and detected FG,PT,PA in plasm before and after administriting defibrase in double-blinded control groups. Result The number of significant progress in treatment group is much higher than that in the control group(P<0.001).Defibrase significantly decreased plasm FG(P<0.001),but had no effect on PT,PA. Conclusion Defibrase is effective in treating acute cerebral infarction,this result is related to decrease of FG in plasm. [