白芍总苷治疗原发性干燥综合征临床疗效观察

The Clinical Eicacy of Total Glucosides of Peony in the Treatment of Primary Sj gren's Syndrome

目的观察白芍总苷治疗原发性干燥综合征的疗效及不良反应。方法收集2008年1月-2012年1月诊断的原发性干燥综合征患者48例,使其口服白芍总苷0.3～0.6 g,3次/d,疗程6个月,对比治疗前后患者的临床症状及唾液腺功能(唾液腺核素显像定量分析)改善情况、泪液分泌试验(Schirmer试验)、血沉、C反应蛋白、血清γ球蛋白(采用琼脂糖凝胶电泳法)的改善情况,并记录可能的不良反应。结果经过6个月的治疗,患者的临床症状、血沉、C反应蛋白、血清γ球蛋白等方面情况有所改善,差异有统计学意义(P<0.05)。但唾液腺功能、Schirmer试验改善不明显,差异无统计学意义(P>0.05)。结论白芍总苷在改善原发性干燥综合征临床症状及实验室指标疗效好,不良反应少,但在改善唾液腺功能及泪腺功能疗效欠佳。

Objective To observe the efficacy and adverse effects of total glucosides of peony （TGP） in the treatment of primary Sj6gren＇s syndrome. Methods From 2008 to 2012, 48 patients diagnosed with primary Sj6gren＇s syndrome in our department received oral total glucosides of peony, 0.3-0.6 g, thrice per day, for 6 months. Clinical symptoms and salivary gland function before and after the treatment （salivary gland radionuclide scan） were compared with respect to the improvement. Data regarding Schirmer test, erythrocyte sedimentation rate, C-reactive protein, serum y-globulin （agarose gel electrophoresis） and adverse reactions were all collected. Results After six months of treatment, patients＇ clinical symptoms, erythrocyte sedimentation rate, C-reactive protein, serum gamma-globulin, had a significant improvement （P 〈 0.05）. Salivary gland function, Schirmer test got no significant improvement （P 〉 0.05）. Conclusion Total glucosides of peony may be effective in improving clinical symptoms, laboratory indicators and adverse reactions of primary Sj6gren＇ s syndrome, but is not so effective in improving salivary gland function and lacrimal gland function.