四种穿心莲二萜内酯类化合物的生物转化

Biotransformation of 4ent-labdane diterpenoid lactones of Andrographis paniculata:recent progress

穿心莲二萜内酯类化合物是穿心莲的特征性成分,具有抗菌、抗病毒、抗炎、解热和抗癌等广泛的药理作用。本文主要从转化底物及转化涉及的反应类型、转化体系、转化产物的构效关系等三方面综述了4种穿心莲二萜内酯在生物转化方面的研究情况,并就目前存在的问题及前景展望进行简要陈述,以期为进一步研究穿心莲二萜内酯类化合物的生物转化提供参考。

Ent-labdane diterpenoid lactones, the principal constituents of Andrographis paniculata, have a wide range of pharmacological effects, such as antibacterial, anti-viral, anti-inflammatory, antipyretic, and anti-cancer effect, etc. In this review the biotransformations of four principal ent-labdane diterpenoid lactones of A. paniculata are discussed from the following aspects： substrates and types of reaction, transformation systems, and structure activity relationships. Moreover, the currently-existing problems and the prospects are also described to provide reference for further studying the biotransformation of ent-labdane diterpenoid lactones of A. paniculata.