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应该高度关注维生素D在人体中的广泛生物学作用 被引量:12

More attention should be paid to the comprehensive biological effects of vitamin D on human beings
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摘要 维生素D是一种脂溶性维生素。其在人体内经过肝脏和肾脏羟化后成为一种重要的激素,即1,25-二羟维生素D3。这种激素不仅促进肠道钙磷的吸收,维护骨骼的健康,还可刺激人体内的巨噬细胞分泌一种抗菌蛋白(cathelicidin),能有效吞噬包括病毒和细菌在内的多种微生物。适量补充维生素D对于维护人体健康十分重要。 Vitamin D is one of the fat-soluble vitamins which, eventually through activation in the liver and kidneys within the human body, becomes an important hormone——1,25-dihydroxyvitamin D3. Not only may 1,25-dihydroxyvitamin D3 promote calcium and phosphate absorption by the intestine, but also stimulate the macrophages to secrete a protein(cathelicidin) which is able to digest the microbacterias, including viruses and bacteria, playing an antiinfective effects. Theofore, a proper supplementation of vitamin D would be beneficial for human health.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2013年第10期825-826,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 维生素D 抗感染 肠钙磷吸收 Vitamin D Antiinfection Intestinal absorption of calcium and phosphate
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  • 1袁志敏,饶中和.甲状旁腺素与原发性高血压[J].临床荟萃,1994,9(2):51-53. 被引量:1
  • 2赵睿珊,王辅才,朱文萍,胡晓东,吴代英.甲状旁腺高血压因子与原发性高血压的关系[J].中华内分泌代谢杂志,1996,12(3):141-143. 被引量:2
  • 3王凤英,卢思广,赵彤,李国民.系膜增生型原发性肾病综合征患儿细胞毒性T淋巴细胞相关抗原4基因多态性、蛋白表达及外周血淋巴细胞凋亡的研究[J].中华儿科杂志,2007,45(8):633-634. 被引量:5
  • 4Holick MF. Vitamin D deficiency. N Engl J Med, 2007,357 : 266- 281.
  • 5Bjelakovic G, Gluud LL, Nikolova D, et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev, 2011,7 : CD007470.
  • 6Venkatram S, Chilimuri S, Adrish M, et al. Vitamin D deficiency is associated with mortality in the medical intensive care unit. Crit Care, 2011,15 : R292.
  • 7Matthews LR, Ahmed Y, Wilson KL, et al. Worsening severity of vitamin D deficiency is associated with increased length of stay, surgical intensive care unit cost, and mortality rate in surgical intensive care unit patients. Am J Surg, 2012,204:37-43.
  • 8Braun AB, Gibbons FK, Litonjua AA, et al. Low serum 25- hydroxyvitamin D at critical care initiation is associated with increased mortality. Crit Care Med, 2012,40:63-72.
  • 9Aruson Y, Gringanz I, hzhaky D, et al. Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patients. QJM, 2012,105:633-639.
  • 10Nair P, Lee P, Reynolds C, et al. Significant perturbation of vitamin D- parathyroid-calcium axis and adverse clinical outcomes in critically ill patients. Intensive Care Med, 2013,39:267-274.

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  • 1Daniel H, Bessesen F . Update on obesity [ J ]. J Clin Endocrinol Metab, 2008,93( 11 ) :2027-2034.
  • 2Mariano M, Lisa CL, Maria PG, et al. L-camitine treatment re- duces severity of physical and mental fatigue and increases cogni- tive functions in centenarians: a randomized and controlled clinical trial[J]. Am J Clin Nutr, 2007,86(9) :1738-1744.
  • 3Botella JI, Alvarez BF, Villafruela JJ, et al. Vitamin D deficiency is associated with the metabolic syndrome in morbid obesity [ J ]. Clin Nutr, 2007,26(4) :573-580.
  • 4Ribas GS, Vargas CR, Wajner M. L-eamitine supplementation as a potential antioxidant therapy for inherited neurometabolic disor- ders[J]. Gene, 2014,533(2) :1108-1112.
  • 5Ribas GS, Biancini GB, Mescka C . Oxidative stress parameters in urine from patients with disorders of propionate metabolism: a ben- eficial effect of L-carnitine supplementation[ J]. Cell Mol Neurobi- ol, 2012,32( 1 ) :4218-4232.
  • 6Meyburg J, Shulze A, Kohlmuell D, et al. Postnatal changes in neonatal acylcarnitine profile [ J ]. Pediatr Res, 2001,49 ( 2 ) : 125- 129.
  • 7Gabriel QS, Martha LC, Marc JW, et al. Adiponectin independ- ently predicts metabolic syndrome in overweight latina youth [ J ]. J Clin Endocrinol Metab, 2007,92 (5) : 1809-1813.
  • 8Malaguarnera M,Vacante M, Avitabile T, et al. L-Carnitine sup- plement ation reduces oxidized LDL cholesterol in patients with dia- betes[J]. Am J Clin Nutr, 2008,89(9) :1-6.
  • 9Pascal BG, Laurent D, Zhen YD, et al. Regulation of lipid flux between liver and adipose tissue during transient hepatic steatosis in camitine-depleted rats [ J ]. J Biol Chem, 2007, 282 ( 10 ) : 20816-20826.
  • 10Modrego JL, Heras N, Zamorano-Leon JJ, et al. Changes in cardi- ac energy metabolic pathways in overweighed rats fed a high-fat diet [J]. Euro J nutri, 2013,52(2):847-856.

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