维生素D缺乏与危重症

Vitamin D deficiency and critical illness

近年来研究发现维生素D不仅是调节钙磷代谢、保持骨骼健康的关键因子,还具有免疫调节、抗增殖、诱导分化和促进凋亡的作用。危重患者是维生素D缺乏的高危人群,维生素D缺乏与疾病严重程度和不良后果相关。维生素D的生物多效性决定了其在遏制危重病发生发展中可能扮演着重要角色,有望成为危重患者的辅助治疗手段。

There is growing awareness of the importance of vitamin D beyond maintenance of musculoskeletal health. Vitamin D has been shown to have extensive biological functions, including modulating immune function, inhibiting cellular proliferation, inducing differentiation, promoting apoptosis. Vitamin D deficiency is highly prevalent in critically ill patients, and it may impact the severity of illness and contribute to less-than-optimal outcomes. Vitamin D plays an important role in preventing the development of critical illness based on its pleiotropic actions, thus holding a profound prospective with respect to an adjunctive therapy in critically ill patients.