部分肝切除术后肝再生的最新研究进展

Research progress of liver regeneration after partial hepatectomy

当前部分肝切除术（PH）作为外科治疗肝癌的首选方法仍被广泛应用，而术后肝脏再生能力则直接关系到患者的预后。因此，肝再生过程及其具体机制以及相关细胞因子研究成为近年来的热点。文献报道了许多与肝再生过程密切相关的基因表达及信号调控通路，但其具体作用机制和它们的相互作用方式仍不十分清楚。尤其是伴有肝炎、肝硬化等基础疾患的肝脏术后再生机制更有待进一步研究。本文就目前关于PH后肝再生过程、再生机制、硬化肝脏再生等方面的研究进展作一综述。

Partial hepatectomy （PH） is widely used and the preferred method for the surgical treatment of hepatocellular carcinoma, and liver regeneration is directly related to the prognosis of the patients after the operation. Therefore, the specific mechanism and cytokines related to liver regeneration have become a hot topic in recent years. Currently, there is a wide variation of reported gene expressions and signal transduction pathways in the literature, but the mechanism and interactions are still unclear, especially for postoperative liver regeneration with hepatitis or cirrhosis. This review summarizes current research on the liver regeneration process, the mechanism of liver regeneration after partial hepatectomy, and the different mechanisms of hepatocirrhosis.