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非诺贝特和吡格列酮干预对代谢综合征大鼠PPAR-α、PPAR-γ表达的影响

Effect of fenofibrate and pioglitazone interventions on the expression of PPAR-α and PPAR-γ in rats with metabolic syndrome
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摘要 目的探讨非诺贝特(FEN)和吡格列酮(PIO)对代谢综合征(MS)大鼠的影响。方法用高果糖饮食饲养SD大鼠构建MS大鼠模型,分别单用FEN、PIO及二者合用进行干预,比较两种药物单用及合用干预下,MS大鼠过氧化物酶体增殖物激活受体-α(PPAR-α)、过氧化物酶体增殖物激活受体-γ(PPAR-γ)表达指标间的差异。结果单用FEN干预使MS大鼠主动脉表达PPAR-α和PPAR-γmRNA及其蛋白降低,单用PIO干预使MS大鼠主动脉表达PPAR-γmRNA及其蛋白降低,使PPAR-αmRNA表达降低;合用FEN与PIO较两种药物单用更为明显地降低了PPAR-αmRNA及其蛋白表达水平,对于PPAR-γmRNA和蛋白表达影响则与PIO干预类似。结论 FEN与PIO单独应用及联合应用干预,均可抑制MS大鼠主动脉表达PPAR-α/γ,联合应用比单独应用更明显地抑制PPAR-α表达。 Objective To explore the effect of fenofibrate (FEN) and pioglitazone (PIO) on rats with metabolic syndrome (MS). Methods A rat model with metabolic syndrome was established by treating the SD rats with high-fructose diets. The rats were then separately treated with PPAR-α or -γ agonists FEN, PIO, or the combination of both. The expression indexes of PPAR-α and PPAR-α in those MS rats were compared. Results The expression levels of PPAR-α mRNA, PPAR-γ mRNA and their proteins in the aorta from FEN and PIO intervention groups were lower than the MC group. The combined treatment with FEN and PIO could greatly reduce the expression levels of PPAR-α mRNA and the protein. However, the expression levels of PPAR-γ mRNA and protein were similar to the PIO intervention group. Conclusion FEN or PIO alone can suppress the expression of PPAR-α/γ, in the MS rat model. The combined treatment with FEN and PIO has a greater effect than the application of either FEN or PIO in the suppression of the expression of PPAR-α.
出处 《热带医学杂志》 CAS 2013年第9期1068-1071,共4页 Journal of Tropical Medicine
基金 广东省自然科学基金(2010B031600198) 深圳市龙岗区科技项目(YS2011033)
关键词 代谢综合征 过氧化物酶体增殖物激活受体-Α 过氧化物酶体增殖物激活受体-Γ metabolic syndrome peroxisomal proliferator-activated receptor-α peroxisomal proliferator-activated receptor-γ
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