儿童痰培养肺炎链球菌耐药性分析

Antibiotic resistance of Streptococcus pneumoniae of children′s sputum

目的了解儿童呼吸道感染肺炎链球菌对常用抗菌药物的敏感性,以便有效指导临床合理用药。方法对唐山市滦县中医院儿科2009-2012年分离的肺炎链球菌进行分析,菌株鉴定采用美国BD公司PhoenixTM100全自动鉴定药敏分析仪,用参考菌株做质量控制。结果2009-2012年肺炎链球菌检出率分别为7.27%(263/3 620)、8.11%(419/5 165)、9.20%(425/4 621)、10.67%(503/4 715),总体呈增长趋势;肺炎链球菌耐药性亦有增加趋势,大环内酯类药物最为明显,达到97%以上;头孢菌素类敏感性虽稍有下降,但敏感率仍在92%以上。结论儿童呼吸道肺炎链球菌携带率相对较高,感染的阳性率呈逐年升高趋势,耐药率逐渐增加。

Objective To understand the drug resistance of Streptococcus pneumoniae in the pediatric sputum culture, and provide the reference for clinical rational use of drugs. Methods Court Streptococcus pneumoniae isolated from pediatric sputum culture from 2009 to 2012, were identified using the U.S. BD PhoenixTM100 fully automatic identification of susceptibility analyzers, quality controlled with reference strains. Results From 2009 to 2012, the detection rate of Streptococcus pneumoniae were 7.27%, 8.11%, 9.20%, and 10.67%, respectively; the overall positive rate was increasing; the most obvious of increased resistance was Large ring lactone class of drugs, was accounting for more than 97% ; cephalosporin class sensitivity was although a slight decline, but sensitive rate was still above 92%. Conclusion Childhood respiratory Streptococcus pneumoniae carried rate was relatively high. Infection positive rate showed a trend of increased year by year, and drug resistance also increased gradually.