猫扣带回前部内脏伤害感受神经元的诱发反应

Evoked responses of visceral nociceptive neurons in cat anterior cingulate gyrus revealed by intracellular recording techniques

应用玻璃微电极细胞内电位记录技术 ,观察了 2 0只猫扣带回前部 46 1个神经元对电刺激对侧内脏大神经的诱发反应及其电生理特性。在被观察的神经元中 ,176个为刺激相关神经元。根据诱发反应的特性 ,将其分为特异性内脏伤害感受神经元 (114个 ,6 4 77% )、非特异性内脏伤害感受神经元 (34个 ,19 32 % )及非内脏伤害感受神经元 (2 8个 ,15 91% )。诱发反应分为兴奋性 (5 9 46 % )、抑制性 (2 2 30 % )及混合性反应 (18 2 4% )三种。2 85个为刺激非相关神经元。结果提示 ,内脏大神经的传入通路投射到对侧的扣带回前部 ;扣带回前部存在内脏伤害感受神经元 ,可分为两种类型 ,它们在痛觉的感受及调制中可能起不同的作用。

With intracellular recording techniques, we investigated evoked responses and elec^tro^physiol^ogical properties of neurons in anterior cingulate gyrus (ACG) to stimulating greater splanchnic nerve (GSN) in cats. Among 461 neurons, 176 were stimulus relative and 285 stimulus irrelative. According to the char^ac^teristics of the evoked responses, stimulus relative neurons were classified into specific visceral nociceptive neurons (SVNNs, 64 77%), non specific visceral nociceptive neurons (NSVNNs, 19 32%) and non visceral nociceptive neurons (NVNNs, 15 91%). Modes of the evoked responses could be excitatory, inhibitory, or mixed ones. The results suggest that ACG may be one of the representative areas of the GSN afferent pathway, and there exist two kinds of VNNs in ACG, which may be differently involved in pain modulation. [WT5HZ]