细菌生物膜及其在眼部疾病中的研究进展

The research progress of biofilm and biofilm in eye disease

细菌生物膜（BBF）指细菌吸附于活性或非活性表面后,分泌多糖蛋白复合物,使细菌相互粘连并将其自身包裹其中形成的膜状物.相对于浮游细菌,BBF其毒力、耐药性均大大增强,同时也能导致机体的免疫损伤.医学常见生物膜相关感染涉及临床各科,其在众多眼部感染中起着非常重要的作用.本文就对BBF的概念、生物学特性以及眼科BBF相关感染做一综述.

Bacteria adherent on the active or inactive surface can form biofilms in which they are encased in a hydrated matrix of extracellular polymeric substances,which is so called bacterial biofilm （BBF）.BBF has greater virulence and drug resistance,they can also evade the host immune system and lead to immune injury compared with planktonic bacteria.Many common medical infections involving ophthalmic infection are biofilm-associated.In this paper,the concept and biological characteristics of BBF and BBF-related ophthalmic infection were reviewed.