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自噬与视神经炎相关性研究进展

The latest advance of correlation between autophagy and optic neuritis
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摘要 视神经炎是一组引起急性、亚急性视力减退的视神经炎症性疾病,其确切发病机制尚未十分清楚.自噬是真核细胞内一条重要的代谢途径,它在降解受损的细胞器、蛋白质等以维持细胞内环境稳态方面有重要作用,它与多种疾病的发生发展有着密切的关系.本文就自噬参与视神经炎的发病及其调控关系做一综述. Optic neuritis is an inflammatory disease of the optic nerve with an abrupt loss of vision.The mechanism of the disease is not completely clear.Autophagy is an important metabolic pathway of eukaryotic cells involved degrading and recycling damaged organelles and proteins to maintain intracellular homeostasis.It is involved in the pathogenesis of various diseases.In this article,the probable effects of autophagy in the mechanism of optic neuritis is reviewed.
作者 施祥 吴云成 朱潇颖 孙晓东
机构地区 上海交通大学附属第一人民医院眼科 上海交通大学附属第一人民医院神经内科
出处 《中华眼科杂志》 CAS CSCD 北大核心 2013年第10期956-959,共4页 Chinese Journal of Ophthalmology
关键词 视神经炎 自噬 多发性硬化 Optic neuritis Autophagy Multiple sclerosis
分类号 R774.6 [医药卫生—眼科]
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参考文献46

  • 1赖春涛,李伟,孙彦斌,孟超,赤克美,陆长峰,余华峰,张志欣.视神经炎患者临床特征及与人白细胞抗原的相关性研究[J].中华眼科杂志,2006,42(6):501-506. 被引量：6
  • 2Balcer LJ.Clinical practice.Optic neuritis.N Engl J Med,2006,354:1273-1280.
  • 3Hasan KM,Walimuni IS,Abid H,et al.Human brain atlas-based multimodal MRI analysis of volumetry,diffusimetry,relaxometry and lesion distribution in multiple sclerosis patients and healthy adult controls:implications for understanding the pathogenesis of multiple sclerosis and consolidation of quantitative MRI results in MS.J Neurol Sci,2012,313:99-109.
  • 4Mahad DJ,Ziabreva I,Campbell G,et al.Mitochondrial changes within axons in multiple sclerosis.Brain,2009,132:1161-1174.
  • 5Schirmer L,Antel JP,Bruck W,et al.Axonal loss and neurofilament phosphorylation changes accompany lesion development and clinical progression in multiple sclerosis.Brain Pathol,2011,21:428-440.
  • 6Levine B.Eating oneself and uninvited guests:autophagy-related pathways in cellular defense.Cell,2005,120:159-162.
  • 7Mizushima N,Levine B,Cuervo AM,et al.Autophagy fights disease through cellular self-digestion.Nature,2008,451:1069-1075.
  • 8Gammoh N,Florey O,Overholtzer M,et al.Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and-independent autophagy.Nat Struct Mol Biol,2012,20:144-149.
  • 9Hosokawa N,Hara T,Kaizuka T,et al.Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.Mol Biol Cell,2009,20:1981-1991.
  • 10Ohashi Y,Munro S.Membrane delivery to the yeast autophagosome from the Golgi-endosomal system.Mol Biol Cell,2010,21:3998-4008.

二级参考文献20

  • 1赖春涛,杨凌,尚军,张晓君,王景群,王薇,秦朝晖,王虔,孙林,余华峰.Leber遗传性视神经病的线粒体基因突变及临床特征[J].中国神经精神疾病杂志,2005,31(1):8-10. 被引量：4
  • 2Beck RW,Trobe JD,Moke PS,et al.High-and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis:experience of the optic neuritis treatment trial.Arch Ophthalmol,2003,121:944-949.
  • 3Kelly MA,Cavan DA,Penny MA,et al.The influence of HLA-DR and-DQ alleles on progression to multiple sclerosis following a clinically isolated syndrome.Hum Immunol,1993,37:185-191.
  • 4Jacobs LD,Kaba SE,Miller CM,et al.Correlation of clinical,magnetic resonance imaging,and cerebrospinal fluid findings in optic neuritis.Ann Neurol,1997,41:392-398.
  • 5Optic neuritis study group.The clinical profile of optic neuritis:experience of the optic neuritis treatment trial.Arch Ophthalmol,1991,109:1673-1678.
  • 6Wakakura M,Minei-Higa R,Oono S,et al.Baseline features of idiopathic optic neuritis as determined by a multicenter treatment trial in Japan.Jpn J Ophthalmol,1999,43:127-132.
  • 7Optic neuritis study group.The 5-year risk of MS after optic neuritis:experience of the optic neuritis treatment trial.Neurology,1997,49:1404-1413.
  • 8Cole SR,Beck RW,Moke PS,et al.The predictive value of CSF oligoclonal banding for MS 5 years after optic neuritis.Neurology,1998,51:885-887.
  • 9Soderstrom M,Ya-Ping J,Hillert J,et al.Optic neuritis:prognosis for multiple sclerosis from MRI,CSF,and HLA findings.Neurology,1998,50:708-714.
  • 10Chan C,Mackey DA,Byrne E.Sporadic Leber hereditary optic neuropathy in Australia and New Zealand.Aust N J Ophthalmol,1996,24:7-14.

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中华眼科杂志
2013年 第10期

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