摘要
肝纤维化(hepatic fibrosis,HF)发生的中心环节是肝星状细胞(hepatic stellate cells,HSCs)的活化,实质是细胞外基质(extracellular matrix,ECM)的合成大于降解。TGF-β1不仅影响HSC的活化,还影响ECM的合成与降解,故在HF的发生发展中起重要作用。本文通过对TGF-β1的信号通路及其信号通路间的对话(crosstalk)来阐述TGF-β1与HF的关系。
lular matrix synthesis this articl crosstalk. The key of hepatic fibrosis is the activation of hepatic stellate cells （ HSCs）. And the ECM） synthesis more than degradation. TGF-β1 not only affects the activation of HSC, degradation of ECM. So it plays an important role in the occurrence and development to illustrate the relationship between TGF-β1 and HF through the signal pathways of essence is extracel- but also affects the of HF. The aim of TGF-β1 and their
出处
《胃肠病学和肝病学杂志》
CAS
2013年第10期955-958,共4页
Chinese Journal of Gastroenterology and Hepatology
