胃黏膜肥大细胞及其脱颗粒与消化性溃疡关系的研究

Research of mucosal mast cell and its degranulation in peptic ulcer

目的探讨胃黏膜肥大细胞(mast cell,MC)在不同消化性溃疡中的分布特点。方法对消化性溃疡患者胃窦黏膜组织进行HE染色及肥大细胞免疫组化染色,比较各型消化性溃疡中胃黏膜MC计数及其脱颗粒特点。结果消化性溃疡组MC平均值为18.02±3.96,高于正常组13.30±3.03,差异有统计学意义;消化性溃疡组脱颗粒率为(18.87±11.81)%,正常组为(32.07±14.53)%,两组间比较差异有统计学意义;GU+DU(复合性溃疡)MC脱颗粒率为(41.99±24.42)%,明显高于GU组(29.75±12.78)%及DU组(30.05±11.66)%,差异有统计学意义(P<0.05)。结论胃窦黏膜MC脱颗粒的增多与复合性溃疡的形成有相关性。

Objective To investigate the character of mucosal mast cell （MC） in different category peptic ulcer （PU）. Methods The gastric antrum mucosal tissue was dyed by hematoxylin-eosin staining and mast cells were dyed by immunohistochemisty staining, the number and degranulation of gastric antrum mucosal MC were compared in differ- ent PU. Results The number and degranulation of gastric antrum mucosal MC in the group of PU （18.02 ± 3.96, 18. 87 ± 11.81 ） were higher than the normal group （13.30±3.03,32.07 ± 14.53）, the degranutation of MC in the com- pound ulcer group （41.99 ± 24.42 ） showed higher than GU （29.75 ± 12.78 ） and DU （30.05 ± 11.66） group（P 〈 0.05）. Conclusion There are relationships between gastric antrum mucosal MC degranulation and the development of compound ulcer.