腹水中CD8^+ CD28^-T细胞表达水平对良恶性腹水的鉴别价值

The expression of CD8^+ CD28^- T cells in the benign and malignant diagnosis of ascites

目的探讨良恶性腹水中CD8+CD28-T细胞表达水平及意义,以便为良恶性腹水的鉴别诊断提供新的思路和方法。方法采用流式细胞仪检测24例肝硬化性腹水、20例结核性腹水、28例恶性腹水中CD8+CD28-T细胞表达水平。结果恶性腹水组CD8+CD28-T细胞表达水平为(24.75±4.09)%,明显高于结核性腹水组(13.83±2.38)%及肝硬化性腹水组(16.15±1.49)%,后两组比较差异有统计学意义(P<0.05)。结论 CD8+CD28-T细胞表达水平在良恶性腹水中存在显著差异,可作为判定良恶性腹水的辅助诊断指标。

Objective To study the expression new technology for the early diagnosis of malignan of CD8 ＋ CD28 - T cells in benign and malignant ascites and provide a t ascites. Methods Flow cytometry was used to test the levels of CD8 ＋ CD28-T cells in hepatocirrhosis ascites （n = 24）, tuberculous ascites （n = 20） and malignant ascites （n = 28）. Results The percent of CD8 ＋ CD28 - T cells in malignant ascites group （24.75 ± 4.09） % was higher than that in hep- atocirrhosis ascites group （ 16.15 ± 1.49） % and tuberculous ascites group （ 13.83 ± 2.38） % , there was statistically significant difference between hepatocirrhosis ascites and tuberculous ascites groups （P 〈 0.05）. Conclusion CD8 ＋ CD28-T ceils is significantly different between malignant ascites hepatocirrhosis ascites and tuberculous ascites, they could be used to distinguish malignant ascites from hepatocirrhosis and tuberculous.