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小剂量过氧化氢预处理对大鼠心肌缺血/再灌注损伤的保护作用 被引量：5

Attenuation of cardiac ischemia/reperfusion injury by transient low hydroperoxide pretreatment in rat
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摘要 目的:探索小剂量过氧化氢预处理与心脏缺血/再灌注损伤之间的关系。方法:SD大鼠随机分为4组,即假手术组、缺血/再灌注组(I/R)、缺血预适应组(IPC)及小剂量过氧化氢预处理组。对各组的心功能与心肌损伤指标进行比较。结果:IPC能够明显保护再灌注损伤,改善心功能。小剂量H2O2预处理能够达到与IPC类似的功效。短暂模拟缺血缺氧导致H2O2产生,小剂量H2O2预处理减少钙超载诱导的细胞色素c释放。结论:IPC导致小剂量H2O2产生,后者通过抑制线粒体通透转换发挥对心肌缺血/再灌注损伤的保护作用。 Objective： To investigate how transient low dose of hydroperoxide pretreatment prevents cardiac ischemia/reperfusion injury.Methods： SD rats were divided into 4 groups：sham operation（Sham）,standard ischemia/reperfusion（I/R）,ischemic preconditioning（IPC） and IR preceded by low H2O2 treatment.Cardiac function and injury parameter were compared among groups.Results： IPC protected reperfusion injury and improved cardiac function.Low H2O2 treatment played a role in cardioprotection similar to IPC.Low H2O2 was indeed generated in the early phase of simulated ischemia and attenuated cytochrome c release induced by high Ca2＋ in isolated mitochondria.Conclusion： Low H2O2 plays a critical role in cardioprotection probably by inhibiting mitochondrial permeability transition.
作者 冯润荷 张金财 李小倩 孙海丽 刘斌 赵蕴珍 唐向东 李静
机构地区 天津医学高等专科学校 南开大学医学院
出处 《中国应用生理学杂志》 CAS CSCD 2013年第3期247-250,共4页 Chinese Journal of Applied Physiology
基金 天津市自然科学基金(10JCYBJC14800) 国家自然科学基金(81072629) 天津市教委科研计划项目(20100115)
关键词 再灌注损伤 缺血预适应 心肌保护 过氧化氢 reperfusion injury ischemic preconditioning cardioprotection hydroperoxide
分类号 R966 [医药卫生—药理学] R363 [医药卫生—病理学]
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参考文献10

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同被引文献48

  • 1綦俊,杨双强.细胞信号转导在心肌缺血预适应中的研究进展[J].心血管病学进展,2006,27(z1):4-7. 被引量：2
  • 2杜萍,冷吉燕,付军,何娜.胰激肽原酶对自发性高血压大鼠氧化损伤和心肌纤维化的影响[J].中国老年学杂志,2006,26(7):941-942. 被引量：5
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  • 6Chen J, Mehta JL, Haider N, et al. Role of caspases in Ox-LDL - in- duced apoptotic cascade in human coronary artery endothelial cells [J]. Circ Res, 2004, 94(3): 370-376.
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中国应用生理学杂志
2013年 第3期

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