摘要
目的观察紫杉醇联合奥沙利铂-线治疗进展期胃癌的疗效和毒副反应。方法96例进展期胃癌患者接受紫杉醇＋奥沙利铂方案一线化疗。紫杉醇100～135mg／m^2dl，奥沙利铂75—85mg／m^2d2。14天为一个周期。结果客观有效率（ORR）52．08％，疾病控制率（DCR）94．79％，中位无疾病进展期（Pvs）7．2个月（95％CI6．023～8．377），中位总生存时间（OS）11．7个月（95％CI10．094—13．306）。主要毒副反应为中性粒细胞减少、白细胞减少、贫血、血小板减少、恶心、呕吐、腹泻、末梢神经毒性、乏力、转氨酶升高。结论以紫杉醇联合奥沙利铂方案一线治疗进展期胃癌，近期疗效好，疾病控制率高，毒副反应可耐受，可作为进展期胃癌的一线治疗方案。
Objective To investigate the effect and side effects of paclitaxel plus oxaliplatin as the first - line thera- py for advanced gastric cancer. Methods 96 patients with adanced gastric cancer received paclitaxel （ 100 - 135 mg/m： day 1 ） plus oxaliplatin （75 -85 rag/m2 day 2） as the first -line therapy, 14 days for a cycle. Results Objective re- sponse rate（ORR） was 52.08%. Disease control rate （DCR） was 94.79%. The median progress - free survival （PFS） was 7.2 months （95 % CI 6. 023 - 8. 377 ）. The median overall survival time （OS） was 11.7 months （ 95 % CI 10. 094 - 13. 306）. Neutropenia, leucopenia, anemia, thrombocytopenia, nausea and vomiting, diarrhea, peripheral nerve toxici- ty, fatigue, transaminase lifts were the main side effects. Conclusion The therapeutic effect of paclitaxel plus oxaliplatin as the first - line therapy for advanced gastric cancel is good, with high disease control rates and tolerable side effects. So can be the first -line therapy for advanced gastric cancer.
出处
《徐州医学院学报》
CAS
2013年第10期654-657,共4页
Acta Academiae Medicinae Xuzhou
关键词
化学治疗
胃癌
紫杉醇
奥沙利铂
chemotherapy
gastric cancer
paclitaxel
oxaliplatin
