血清肝纤维化标志物指标在肝纤维化病理分期诊断中的应用

Clinical value of serum hepatic fibrosis In the diagnosis of liver fibrosis

目的:探讨血清肝纤维化标志物诊断肝纤维化病理分期的临床价值。方法:回顾47例慢性乙肝患者,通过对血清肝纤维化相关指标(HA、IV-C、PIIIP和LN)检测,分析各指标对诊断早期肝硬化的敏感度和特异性,探讨血清肝纤维化相关指标与肝纤维化病理分期相关性。结果:血清肝纤维化相关指标与肝纤维化病理分期相关性大小顺序为:r(IV-C=0.63)>r(PIIIP=0.40)>r(HA=0.28),而LN相关性检验无统计学意义(P>0.05)。各相关指标经ROC曲线分析,对肝硬化诊断敏感度大小顺序为IV-C(82.0%)>PIIIP(80.1%)>HA(49.2%),对肝硬化诊断特异度大小顺序为HA(74.1%)>IV-C(71.3%)>PIIIP(69.3%)。结论:血清肝纤维化指标能较好的反映肝纤维化病理分期情况。

Objective To investigate the serum liver fibrosis diagnosis of liver fibrosis staging clinical value. Methods 47 patients with chronic hepatitis B information, through the serum fibrosis related indicators （HA, IV -C, PIIIP and LN） detection, calculation and liver fibrosis staging correlation statistical methods discussed through various indicators diagnostic sensitivity and specificity of early cirrhosis. Results The serum liver fibrosis indexes and liver fibrosis staging order of correlation： r （ IV - C = 0. 63 ） 〉 r （ PIIIP = 0. 40） 〉 r （ HA = 0. 28 ）, but no statistical correlation test LN significance （ P 〉 0.05 ） . The relevant indicators by ROC curve analysis, the sensitivity for the diagnosis of cirrhosis is the order of IV - C （82. 0% ） 〉 PIIIP （80. 1% ） 〉 HA （49. 2% ）, specificity for the diagnosis of cirrhosis is the order of HA （74. 1% ） 〉 IV - C （71.3%） 〉 PIIIP （69. 3% ） . Conclusion Serum fibrosis markers can better reflect the condition of liver fibrosis staging.