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间充质干细胞应用现状及展望 被引量：5

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摘要 间充质干细胞（MSC）是一种来源于组织和器官的多向分化潜能的成体干细胞，具有免疫调节、炎症趋化、组织修复功能及低免疫原性等生物学特性，在组织修复与免疫调节中发挥重要作用。目前，人们已成功地将MSC从骨髓、胎盘、脂肪组织、脐带血、肝脏等组织器官中培养出来。在正常动物中，MSC经静脉输注入体内首先移至骨髓；
作者 陈规划 杨扬 张琪 潘国政
机构地区 中山大学附属第三医院肝移植中心 中山大学器官移植研究所 广东省器官移植研究中心
出处 《中华肝脏外科手术学电子杂志》 CAS 2013年第4期1-3,共3页 Chinese Journal of Hepatic Surgery(Electronic Edition)
基金 国家自然科学基金(U0932006 81000190 81172036 81170451) 广东省自然科学基金(S20120011190 S2012040007964) 广东省科技计划项目(2010B05070003) 广州市科技计划项目(2010J-E121 2011Y1-00033-3) 中央高校基本科研业务费专项资金(10ykjc03 12ykpy43)
关键词 间充质干细胞 多向分化潜能 组织修复 免疫调节 组织器官 成体干细胞 生物学特性 经静脉输注
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献25

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二级参考文献31

共引文献9

同被引文献78

  • 1Xiao-Yong Liu,Jian Chen,Qing Zhou,Jing Wu,Xiao-Ling Zhang,Li Wang,Xiao-Yan Qin.In vitro tissue engineering of lamellar cornea using human amniotic epithelial cells and rabbit cornea stroma[J].International Journal of Ophthalmology(English edition),2013,6(4):425-429. 被引量：10
  • 2万虹,李德志,杨飞,历俊华,王身国,王忠诚.许旺细胞与PLGA共同移植于大鼠全横断脊髓损伤的实验研究[J].中华外科杂志,2007,45(12):843-846. 被引量：13
  • 3Kim N, Cho SG. Clinical applications of mesenchymal stem cells[J]. Korean J Intern Med, 2013, 28 (4): 387- 402.
  • 4Wang L, Zhao C, Peng Q, et al. Expression levels of CD28, CTLA- 4, PD-1 and Tim-3 as novel indicators of T-cell immune function in patients with chronic hepatitis B virus infection [ J]. Biomed Rep, 2014, 2 2) : 270 -274.
  • 5Kloog Y, Mor A. Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rapl [J].Mol Cell Biol, 2014, 34 (6): 978-988.
  • 6Taran R, Mamidi MK, Singh G, et al. In vitro and in vivo neurogenic potential of mesenchymal stem cells isolated from different sources [ J ]. J Biosci, 2014, 39 (1): 157-169.
  • 7Ng CP, Mohamed Sharif AR, Heath DE, et al. Enhanced ex vivo expansion of adult mesenchymal stem ceils by fetal mesenchymal stem cell ECM [ J ] . Biomaterials, 2014, 35 (13) : 4046-4057.
  • 8Ryan AE, Lohan P, O'Flynn L, et al. Chondrogenic differentiation increases antidonor immune response to allogeneic nlesenchymal stem cell transplantation [ J ]. Mol Ther, 2014, 22 (3): 655-667.
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  • 10Sivanathan KN, Gronthos S, Rojas-Canales D, et al. Interferon-gamma modification of mesenchymal stem cells : implications of autologous and allogeneic mesenchymal stem cell therapy in allotransplantation[ J]. Stein Cell Rev, 2014, 10 (3) : 351-375.

引证文献5

二级引证文献22

中华肝脏外科手术学电子杂志
2013年 第4期

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