生长抑素联合泮托拉唑对急性胰腺炎患者炎症介质的影响

Effect of somatostatin and pantoprazole on the inflammatory mediators of acute pancreatitis patients

目的探讨生长抑素联合泮托拉唑对急性胰腺炎患者炎症介质的影响。方法将我院诊治的116例急性胰腺炎患者随机分为2组,两组患者均接受常规治疗,对照组(56例)给予生长抑素静点,观察组(60例)给予生长抑素联合泮托拉唑治疗。比较两组临床症状缓解时间、实验室指标恢复正常时间及血清炎症因子改变情况。结果观察组患者腹痛腹胀、腹水消失时间、恢复进食时间明显短于对照组(P<0.05);与对照组相比,观察组患者血、尿淀粉酶及白细胞恢复正常时间明显缩短(P<0.05);观察组血清超敏C-反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素(IL-6)显著低于对照组(P<0.05)。结论生长抑素联合泮托拉唑治疗急性胰腺炎可降低机体炎症因子水平,提高临床疗效。

Objective To explore the effect of somatostatin and pantoprazole on inflammatory mediators of acute pancreatitis patients. Methods 116 patients with acute pancreatitis were randomly divided into 2 groups. All the patients received routine treatments ; control group （ n = 56 ） was given somatostatin, observation group （ n = 60 ） received somatostatin and pantoprazole. The time of relieving symptoms, the recovery time of laboratory indexes and inflammatory mediators were compared between the two groups. Results The disappearing time of stomachache,hydroperitoneum, the time of resuming to diets in observation group were much shorter than those of control group （ P 〈 0. 05 ） ; compared with control group, the hemodiastase,urine amylase and leukocyte recovered more faster in observation group（ P 〈0. 05）;the levels of serum bs-CRP, TNF-α and IL-6 in observation group were much lower than those of control group（ P 〈 0. 05 ）. Conclusion Somatostatin combined with pantoprazole in the treatment of acute pancreatitis can greatly improve the clinical effect and decrease the serum＇ inflammatory mediators.