青年脑卒中危险因素病例对照研究

Case-control study of risk factors in the young stroke patients

目的探讨青年脑卒中的危险因素，为制定有针对性的干预措施提供依据。方法采用病例对照研究方法，以2009—2011年期间在河北大学附属医院神经内科住院的18～45岁73例青年脑卒中患者为病例组，随机抽取97例18～45岁同期住院的非脑卒中患者为对照组。通过摘抄医院病历中相关信息，并电话随访相关行为，利用∥检验及Logistic回归筛选青年脑卒中危险因素。结果青年脑卒中受高血压病史、糖尿病病史、高血脂病史、脑卒中家族史、一过性黑蒙病史、偏头痛、睡眠呼吸障碍等既往病史影响；受吸烟、饮酒、口味偏咸、口味偏油等生活行为习惯的影响；受空腹血糖生化指标影响。未发现青年脑卒中受性别、职业、外周血管病史、慢性牙周炎、体育锻炼、纤维蛋白原、血清总胆固醇（senlmtotalcholesterol，TC）、甘油三酯（triglyceride，TG）、低密度脂蛋白（10w—densitylipoprotein，LDL）、高密度脂蛋白（high—densitylipoprotein，HDL）、肌酐等的影响。结论青年脑卒中的发生受多种因素的影响，应针对危险因素采取干预措施，降低青年脑卒中的发病率。

Objective To study the risk factors in young stroke patients, and to provide the basis for targeted in- tervention measures. Methods With a case-control study, 73 hospitalized patients for the case group and 97 non-patients for the control group aged 18-45 years old were selected from Department of Neurology, the Affiliated Hospital of Hebei U- niversity during 2009 -2011 year. By copying the information from the hospital medical records and following-up by tele- phones, we analyzed the related influencing factors of stroke in young people with Chi-square test and Logistic regression. Results History of hypertension, history of diabetes, history of high cholesterol, family history of stroke, history of transi- ent amaurosis, history of migraine headaches and respiratory sleep disorders were the influencing factors ; smoking, drink- ing, salty taste, taste biased oil, and were related to stroke and as well. Conclusions Stroke in youth adults were influ- enced by a lot of risk factors, effective interventions should be adopted to reduce the incidence of stroke in young people.