期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血小板源性生长因子及其受体与胃癌的靶向治疗 被引量：2

Piatelet - derived growth factor and its receptor： potential molecular targets for gastric cancer
下载PDF
导出
摘要 血小板源性生长因子（Platelet—derivedgrowthfactor，PDGF）及其受体与肿瘤的发生、新生血管的生成、控制肿瘤组织间隙压以及细胞调亡机制等密切相关，．新近研究发现，通过靶向抑制PDGF及其受体能够有效治疗胃癌，可用于抑制胃癌新血管生成、增强细胞毒性化疗药物的疗效以及靶向干预治疗淋巴结转移的胃癌。现对PDGF在胃癌分子靶向治疗方面的研究进展做一综述。 Platelet -derived growth factor and its receptor have been found to play an important role m cancer initiation, angiogenesis,apoptosis as well as inhibition of tumor stromal pressure. Recently, their inhihitors have specific effects on gastric cancer, which can inhibit angiogenesis, enhance therapeutic effect and reduce tumor growth and lymphatic metastasis in gastric cancer. In the present paper ,we made a review of its inhibitnrs in treatment of gastric cancer.
作者 李涛(综述) 李莎(审校)
机构地区 解放军第 兰州军区总医院
出处 《实用肿瘤学杂志》 CAS 2013年第5期476-480,共5页 Practical Oncology Journal
关键词 血小板源性生长因子 血小板源性生长因子受体 胃癌 分子靶向治疗药物 Platelet - derived growth factor Receptor of platelet - derived growth factor Gastric cancer Targeted molecular drugs
分类号 R730.5 [医药卫生—肿瘤]
  • 相关文献

参考文献24

  • 1Fredriksson L, Li H? Eriksson U. The PDGF family ; fourgene products form five dimeric isoforms [ J ]. CytokineGrowth Factor Rev,2004,15(4) :197 -204.
  • 2Heidin C H,Eriksson U , Ostman A, New members of theplatelet - derived growth factor family of mitogens[ J]. ArchBiochem Biophys, 2002,398 ( 2) :284 - 290.
  • 3Tallquist M, Kazaluaskas A. PDGF signalling in cells andmice[ J]. Cytokine Growth Factor Rev,2004,15(4) :205 -213.
  • 4Govindarajan B,Shah A,Cohen C,et al. Malignant transfor-mation of human cells by constitutive expression of plateletderived growth factor - BB ( PDGF - BB) [ J]. Biol Chem,2005,280(14) :13936 - 13943.
  • 5Zwemer JP, May WA. Dominant negative PDGF - C inhibitsgrowth of Ewing family tumor cell lines [ J ]. Oncogene,2002,21(24) :3847 -3854.
  • 6Uehara H, Kim SJ, Karashima T, et al. Effects of blockingplatelet - derived growth factor receptor signaling in a mousemodel of experimental prostate cancer bone metastases[ J].Natl Cancer Inst,2003,95(6) :458 -470.
  • 7Apte SM, Bucana CD, Killion JJ,et al. Expression of platelet一 derived growth factor and activated receptor in clinicalspecimens of epithelial ovarian cancer and ovarian carcino-ma cell lines[ J]. Gynecol Oncol ,2004,93( 1 ) ;78 - 86.
  • 8Matei D,Chang DD,Jeng MH. Imatinib mesylate(Gleevec)inhibits ovarian cancer cell growth through a mechanism de-pendent on platelet 一 derived growth factor receptor alphaand Akt inactivation [ J]. Clin Cancer Res,2004,10 ( 2 ):681 -690.
  • 9Carvalho I, Milanezl F, Martins A, et al. Overexpression ofplatelet - derived growth factor receptor in breast cancer isassociated with tumor progression [ J ]. Breast Cancer Res,2005,7(5) :788 -795.
  • 10Heinrich MC, Blanke CD, Druker BJ, et al. Inhibition ofKIT tyrosine kinase activity : a novel molecular approach tothe treatment of KIT - positive malignan mcies [ J ] . J ClinOncol ,2002,20(6) :J692-1703.

二级参考文献75

  • 1兰梅,时永全,魏茂富,王淑兰,韩者艺,潘阳林,王晋,乔泰东,樊代明.缺氧诱导因子HIF-1α在胃癌细胞系中的表达和意义[J].现代肿瘤医学,2005,13(1):21-23. 被引量：11
  • 2王燕,孙燕.肿瘤靶向治疗现状和发展前景[J].中华肿瘤杂志,2005,27(10):638-640. 被引量：22
  • 3殷新光,杨志宏,王波,王桂华,曹宁珠.环氧化酶-2蛋白表达及与胃癌生物学特征、预后的关系[J].实用肿瘤学杂志,2006,20(4):265-267. 被引量：2
  • 4Li X, Eriksson U. Novel PDGF family members: PDGF-C and PDGF-D [ J ]. Cytokine Growth Factor Rev, 2003, 14(2): 91-98.
  • 5Katano M, Nakamura M, Fujimoto K, et al. Prognostic value of platelet derived growth factor-A in gastric carcinoma[J]. Ann Surg, 1998, 227(3): 365-371.
  • 6Stiles CD. The molecular biology of platelet derived growth factor[J]. Cell, 1983, 33 (3): 653-655.
  • 7Wang Z, Kong D, Banerjee S, et al. Downregulation of platelet derived growth factor-D inhibits cell growth and angiogenesis through inactivation of notch-1 and nuclear factor-kB signaling[J]. Cancer Res, 2007, 67 (23): 11377- 11385.
  • 8UstachCV, Taube ME, Hurst NJ, et al. A potential oncogenic activity of platelet-derived growth factor-D in prostate cancer progression [J]. Cancer Res, 2004, 64(5): 1722- 1729.
  • 9KongDJ, Li YW, Wang ZW, et al. miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells[J]. Stem Cells, 2009, 27(8): 1712-1721.
  • 10Zhao L, Zhang CQ, Liao G, et al. RNA imediated inhibition of PDGF-D leads t decreased cell growth, invasion and angiogenesis in the SGC-7901 gastric cancer xenograft model[J]. Cancer BiolTherapy, 2010, 9(1): 42-48.

共引文献12

同被引文献13

引证文献2

二级引证文献11

实用肿瘤学杂志
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部