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2型糖尿病环境因素与DNA甲基化的研究进展 被引量：15

The effect of environmental factors and DNA methylation on type 2 diabetes mellitus
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摘要 2型糖尿病(Type 2 diabetes mellitus,T2DM)是由于遗传与环境因素共同作用而引起葡萄糖代谢紊乱的疾病。DNA甲基化修饰的研究发现环境因素可以通过影响DNA甲基化修饰,显著地增加T2DM的患病风险。目前,T2DM环境相关基因的DNA甲基化修饰研究已在人及动物的不同组织中取得进展。此外,T2DM相关基因的甲基化研究主要集中在糖代谢、能量代谢、炎症等。文章系统地综述了目前T2DM致病环境因素与DNA甲基化研究进展。 Type 2 diabetes mellitus （T2DM） is a glucose metabolic disorder driven by both genetic and environmental factors. Recent DNA methylation studies have established that T2DM may be contributed by environmental factors through the regulation of DNA methylation. Human and animal model studies have made much progress on the interaction between DNA methylation of T2DM genes and environmental factors in multiple tissues. Current studies on DNA methylation of T2DM genes mainly focus on glucose and energy metabolism, inflammation, and so on. This review comprehensively in- troduces the DNA methylation studies for the genes involved in T2DM and its related environmental factors.
作者 汤琳琳 刘琼 步世忠 徐雷艇 王钦文 麦一峰 段世伟
机构地区 宁波大学医学院 宁波大学医学院 宁波大学医学院附属医院
出处 《遗传》 CAS CSCD 北大核心 2013年第10期1143-1152,共10页 Hereditas（Beijing)
基金 国家自然科学基金项目(编号:31100919) 浙江省自然科学基金杰出青年项目(编号:LR13H020003) 宁波市科技局/农业与社会发展攻关项目(编号:2012C50032) 宁波市自然科学基金项目(编号:2007A610077,200701A6304004) 宁波大学重点学科项目(编号:XKL11D2117) 宁波大学王宽诚幸福基金项目资助
关键词 2型糖尿病(T2DM) 表观遗传学 DNA甲基化 环境因素 type 2 diabetes mellitus epigenetics DNA methylation environmental factors
分类号 R587.1 [医药卫生—内分泌]
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参考文献75

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共引文献11

同被引文献212

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引证文献15

二级引证文献98

遗传
2013年 第10期

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