MicroRNA对胚胎干细胞的多能性网络调控

The effect of microRNAs on the regulatory network of pluripotency in embryonic stem cells

胚胎干细胞(Embryonic stem cells,ESCs)是一类能够无限增殖和诱导分化为多种类型细胞的干细胞。MicroRNA(miRNA)是一类内源性具有调控基因表达功能的非编码RNA,在ESCs增殖和分化过程中起重要作用。MiRNA可以通过对ESCs多能性网络中的转录因子、细胞周期、表观遗传学、信号转导等方面调控,促使ESCs维持多能性状态。文章重点综述了miRNA的生成过程、调控ESCs多能性的主要miRNA家族以及miRNA对ESCs多能性网络调控作用等内容。

Embryonic stem cells （ESCs） are pluripotent stem cells characterized by their ability to self-renew and their pluripotency to differentiate into all cell types. MicroRNA （miRNA） is a small non-coding RNA molecule which can regu- late transcriptional and post-transcriptional gene expression, and may also play significant roles in regulating proliferation and differentiation of ESCs. The maintenance of pluripotency in ESCs may involve a regulatory network of many factors and pathways regulated by miRNA, which includes ESCs transcription factors, cell cycle regulation, epigenetic modifica- tions as well as intracelluar signal transduction. This review mainly elaborates the biogenesis of miRNA, the miRNA fami- lies regulating the pluripotency of ESCs, and the effect of miRNA on the regulatory network of pluripotency in ESCs.