常见深部机会致病性真菌分子流行病学研究进展

Progress in molecular epidemiology of common deep opportunistic pathogenic fungi

由于抗生素的滥用和免疫缺陷宿主增多等因素,导致一些机会致病性真菌的感染逐年上升,并表现出高致病性、高死率的特点。分子流行病学通过基因分型的方法,结合患者的感染特点及流行病学资料等进行综合分析,从而从分子水平阐明疾病的流行传播情况,对疾病的预防和治疗具有重要的意义。该文试对三种临床常见深部机会致病性真菌(白念珠菌、烟曲霉、隐球菌)的分子流行病学研究进展进行概述。

With the abuse of antibiotics and the increasing number of immuno-compromised patients, the infection rate of the deep opportunistic pathogenic fungi is rising,year by year, with high morbidity and fatality rate. By the method of genotyping, molec- ular epidemiology combines infective characteristics and epidemiological date of patients to analyze, which is of great significance for the prevention and cure of diseases. Progress in molecular epidemiology of three common deep opportunistic pathogenic fungi （ Candida albicans,Aspergillusfumigates, Cryptococcus ） were reviewed in this article.