白念珠菌MAPK信号通路研究进展

Advances in the MAPK signaling pathway of Candida albicans

白念珠菌是人类最常见的条件致病菌。促分裂素原活化蛋白激酶(MAPK链)是真核生物信号传递网络中的重要途径之一,在基因表达调控和细胞质功能活动中发挥关键作用。在白念珠菌中主要有4条MAPK途径:Mkc1途径、Cek1途径、Cek2途径和HOG途径。其中HOG途径在白念珠菌MAPK信号通路起着重要的作用。对于白念珠菌MAPK信号通路的作用及相关调控机制的了解,可以为寻找新的药物作用靶点,治疗念珠菌病提供帮助。

Candida albicans is the most common opportunistic pathogen in humans. Mitogen-activated protein kinase （MAPK） chain is one of the most important ways of eukaryotic signal network and it plays a key role in regulating gene expression in the cyto- plasm functions. There are mainly four MAPK signaling pathways in Candida albicans ： Mkcl, Cekl, Cek2 and HOG. The HOG pathway plays an important role in MAPK signaling pathway of Candida albicans. The understanding about the role of MAPK signa- ling pathway in Candida albicans and related regulatory mechanism will provide help to find new drug targets and the treatment of candidiasis.