结直肠癌根治性手术后复发时间与生存时间的相关性分析

The relationship between time to relapse and survival after curative surgery in colorectal cancer patients

背景与目的：结直肠癌根治性手术后复发率达30％-40％，肿瘤复发影响患者生存时间。本研究旨在探讨结直肠癌复发时间（time to relapse，TTR）与肿瘤临床病理参数的关系，并进一步分析TTR对复发后生存时间的影响。方法：分析辽宁省肿瘤医院收治的375例结直肠癌患者的临床资料、病理结果及随访数据，比较结直肠癌复发与临床资料和病理类型的相关性，并研究TTR与复发后总体生存时间的关系。结果：TTR与确诊时肿瘤分期以及有无肺、肝脏转移密切相关。短期复发（〈2年）与生存时间密切相关，2-5年内复发与5年以上复发的患者，其生存时间差异无统计学意义（P〉0．05）。结论：结直肠癌患者术后复发时间与肿瘤分期及有无肺、肝脏转移密切相关，短期复发是预测复发后生存时间的重要指标。

Background and purpose： The risk of recurrence for colorectal cancer after curative surgery is up to 30%-40%. We aimed to evaluate the relationship between time to relapse （TTR） of colorectal cancer with clinical pathological parameters and overall survival after recurrence. Methods： We carried out the analysis of clinical data, pathological examination and follow up information of 375 colorectal cancer patients who admitted to Liaoning Cancer Hospital. Patients were categorized into relapse at 〈2, 2-5 and 〉5 years following their initial surgery. Results： TTR was associated with the clinical stage at diagnosis and liver or lung metastasis status. Short TTR （〈2 years） was positively associated with survival. However, there was no significant difference in survival between patients who relapsed at 5 years or later compared with those who relapsed between 2 and 5 years. Conclusion： TTR within 2 years is an important predictor of shorter survival for colorectal cancer patients who experienced a relapse.