贵州省HIV感染者或艾滋病患者血液CD4^+T淋巴细胞数量与病毒载量的相关性

Correlation between CD4^+ T cell count and HIV viral load in HIV infectors or AIDS cases in Guizhou province

目的研究贵州省HIV感染者或艾滋病患者血液CD4+T淋巴细胞数量与HIV-1病毒载量的关系。方法每月1次采集74例HIV感染者或艾滋病患者静脉全血样本,检测CD4+T淋巴细胞及HIV-1病毒载量。结果随着HIV-1病毒载量的增加,CD4+T淋巴细胞数逐渐减少。当CD4+T淋巴细胞数>350个/μl时,1.27%的HIV-1病毒载量>105IU/ml;当HIV-1病毒载量>105IU/ml时,94.74%的CD4+T淋巴细胞数<350个/μl。结论贵州省HIV感染者或艾滋病患者血液的CD4+T淋巴细胞数量与HIV-1病毒载量的Log10值呈负相关。建议给HIV-1病毒载量>105IU/ml的患者进行抗病毒治疗。

Objective To study the correlation between CD4＋ T cell count and HIV-1 viral load in HIV infectors or AIDS cases in Guizhou province, China. Methods Blood samples were collected from 74 HIV infectors or AIDS cases once per month for testing HIV-1 viral load and CD4＋ T cell count. Results The CD4＋ T cell count was decreased as the HIV-1 viral load increased. When the CD4＋ T cell count was more than 350 pieces/μl, HIV-1 viral load over 105 IU/ml accounted for 1.27%. When the HIV-1 viral load was more than 105 IU/ml, CD4＋ T cell count less than 350 pieces/μl accounted for 94.74%. Conclusion The HIV-1 viral load（Logl0） and CD4＋ T cell count are negatively correlated in HIV infectors or AIDS cases in Guizhou province. Antiviral therapy is suitable for the patients with HIV-1 viral load 〉10^5 IU/ml.