丙泊酚与七氟烷对麻醉术后认知功能的影响

Influence of propofol and sevoflurane on postoperative cognitive function

目的比较丙泊酚与七氟烷麻醉对患者术后认知功能的影响。方法择期手术患者60例,按不同麻醉方法均分为丙泊酚组和七氟烷组两组。比较两组麻醉恢复期相关指标和术后简易精神状态量表(MMSE)认知功能评分。结果丙泊酚组患者术后睁眼时间为(13.2±5.8)min,拔管时间为(15.3±4.5)min,拔管后语言应答时间为(16.8±4.8)min,均短于七氟烷组的(18.9±7.5)min、(24.7±5.9)min、(26.4±5.3)min(P<0.05)。两组术后认知功能MMSE评分均较术前有所减少,但丙泊酚组术后认知功能MMSE评分高于七氟烷组(P<0.05)。结论丙泊酚和七氟烷全身麻醉均可降低患者术后认知功能,但丙泊酚的影响较七氟烷轻。

Objective To compare the influence of propofol and sevoflurane on the postoperative cognitive function in patients underwent surgery. Methods A total of 60 cases of surgical patients was equally randomized into two groups of A （anesthetized with propo{ol infusion） and B（anesthetized with sevoflurane inhalation）. The recovery-related indicators were recorded and the postoperative cognitive function was evaluated with Mini-Mental State Examination（MMSE） scores on the 1st , 3rd , 7th and 10th day after operation. Results During recovery from anesthesia, the times for eye-opening, extubation and language response were shorter in group A than those in group B [（13.2±5.8） rain vs. （18. 9±7.5） rain, （15.3±4. 5） rain vs. （24.7±5.9） min and （16.8±4. 8） min vs. （26.43±5.3） mini（P〈0.05）. Compared to Before, MMSE scores after operation were reduced, which were greater in group B than those in group A （P〈0. 05）. Conclusion Anesthesia with propofol and sevoflurane can reduce postoperative cognitive function, which is more with sevoflurane than that with propofol.